Department of Pediatrics, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Pediatr Res. 2017 Aug;82(2):285-289. doi: 10.1038/pr.2017.44. Epub 2017 May 17.
BackgroundChildren born small for gestational age (SGA) have higher serum dehydroepiandrosterone sulfate (DHEAS) concentrations than children born appropriate for gestational age (AGA). The overall metabolic risk associated with birth weight is U-shaped, but it is not known whether children born large for gestational age (LGA) have elevated serum DHEAS levels.MethodsA cohort of 49 children born LGA, 56 children born AGA, and 23 children born SGA were studied at 5-8 years of age. Anthropometric data at birth, at the age of 2 years, and at examination were recorded. Fasting blood samples were collected for serum analyses of DHEAS, insulin-like growth factor 1 (IGF-1), and insulin concentrations.ResultsThe children born LGA had lower serum DHEAS levels adjusted for body mass index (BMI) standard deviation score (SDS) and age than the rest of the children. Lower birth weight SDS and higher weight gain during the first 2 years of life predicted higher serum DHEAS levels. Higher serum IGF-1 levels were also associated with higher prevalence of adrenarchal DHEAS levels.ConclusionBeing born LGA was associated with lower DHEAS levels, whereas small birth size and early catch-up growth predicted higher levels. This suggests that genetic or early epigenetic factors have an impact on adrenarche. IGF-1 may be a mediator in this process.
与适于胎龄出生（AGA）的儿童相比，胎龄小的出生体重（SGA）儿童血清脱氢表雄酮硫酸酯（DHEAS）浓度更高。与出生体重相关的总体代谢风险呈 U 型，但尚不清楚出生巨大儿（LGA）儿童是否具有升高的血清 DHEAS 水平。
本研究纳入了 49 名 LGA 出生、56 名 AGA 出生和 23 名 SGA 出生的儿童，对他们进行了 5-8 岁时的研究。记录了出生时、2 岁时和检查时的人体测量数据。采集空腹血样，用于检测血清 DHEAS、胰岛素样生长因子 1（IGF-1）和胰岛素浓度。
校正体重指数（BMI）标准差评分（SDS）和年龄后，LGA 出生的儿童血清 DHEAS 水平低于其他儿童。较低的出生体重 SDS 和生命最初 2 年内体重增加较多，预测血清 DHEAS 水平较高。较高的血清 IGF-1 水平也与更高的肾上腺性 DHEAS 水平的患病率相关。
出生 LGA 与较低的 DHEAS 水平相关，而出生体重较小和早期追赶生长预测更高的 DHEAS 水平。这表明遗传或早期表观遗传因素对肾上腺功能初现具有影响。IGF-1 可能是该过程中的一个中介物。
