Yamaoka K, Miyasaka N, Yamamoto K
First Department of Medicine, Tokyo Medical and Dental University, Japan.
Arthritis Rheum. 1988 Aug;31(8):1014-21. doi: 10.1002/art.1780310812.
We sought evidence of Epstein-Barr virus (EBV) involvement in the mechanism of polyclonal B cell activation in 29 patients with Sjögren's syndrome (SS). Serum levels of anti-viral capsid antigen antibodies of both the IgG and the IgM class were significantly elevated in these patients. Excretion of EBV from the oropharynx was frequently observed, as well. Spontaneously transformed B cell lines that produced a large amount of transforming EBV were established preferentially from SS patients. We also found that an EBV-specific regulatory mechanism was impaired in these patients. Our findings thus provide evidence of the involvement of EBV in patients with SS.
我们探寻了爱泼斯坦-巴尔病毒（EBV）参与29例干燥综合征（SS）患者多克隆B细胞激活机制的证据。这些患者血清中IgG和IgM类抗病毒衣壳抗原抗体水平显著升高。口咽部EBV排出也经常被观察到。优先从SS患者中建立了产生大量转化型EBV的自发转化B细胞系。我们还发现这些患者中EBV特异性调节机制受损。因此，我们的研究结果为EBV参与SS患者发病提供了证据。
