Fujimori Mahmi, França Eduardo Luzia, Morais Tassiane Cristina, Fiorin Vanessa, de Abreu Luiz Carlos, Honório-França Adenilda Cristina
Department of Maternal and Child Health, School of Public Health, University of São Paulo (USP), São Paulo, SP, Brazil.
Department of Biomedicine, Institute of Biological and Health Science - Federal University of Mato Grosso, Barra do Garças, MT, Brazil.
Biofactors. 2017 Mar;43(2):243-250. doi: 10.1002/biof.1339. Epub 2016 Nov 7.
Breast milk contains bioactive components that contribute to newborn development. However, colostrum may undergo biochemical and immunological changes as a function of maternal overweight and obesity. To investigate this hypothesis, this study determined the levels of hormones and immunological markers in the serum and colostrum of overweight and obese mothers. Colostrum and serum samples were collected from 15 normoweight, 15 overweight, and 15 obese women for determination of leptin, adiponectin, cytokines (TNF-α, IL-6, IL-10), and C-reactive protein (CRP). Obese mothers exhibited higher levels of serum TNF-α, IL-6, and CRP, serum and colostrum leptin and colostrum adiponectin and lower levels of serum adiponectin. Leptin levels in maternal serum and colostrum were positively correlated, as was pre-pregnancy BMI and serum TNF-α, IL-6, CRP, and leptin. Adiponectin levels in colostrum and serum were negatively correlated. The results suggest that obesity changes hormonal and immunological components of maternal serum and colostrum. The modifications can have short-term and long-term effects on newborn development. © 2016 BioFactors, 43(2):243-250, 2017.
母乳含有有助于新生儿发育的生物活性成分。然而，初乳可能会随着母亲超重和肥胖而发生生化和免疫变化。为了研究这一假设，本研究测定了超重和肥胖母亲血清和初乳中的激素水平和免疫标志物。收集了15名体重正常、15名超重和15名肥胖女性的初乳和血清样本，以测定瘦素、脂联素、细胞因子（TNF-α、IL-6、IL-10）和C反应蛋白（CRP）。肥胖母亲的血清TNF-α、IL-6和CRP、血清和初乳瘦素以及初乳脂联素水平较高，而血清脂联素水平较低。母亲血清和初乳中的瘦素水平呈正相关，孕前BMI与血清TNF-α、IL-6、CRP和瘦素也呈正相关。初乳和血清中的脂联素水平呈负相关。结果表明，肥胖会改变母亲血清和初乳的激素和免疫成分。这些改变可能会对新生儿发育产生短期和长期影响。©2016生物因子，43(2):243 - 250，2017。
