脑血氧水平依赖性功能磁共振成像的神经血管耦合在正常衰老过程中无显著变化。
BOLD neurovascular coupling does not change significantly with normal aging.
作者信息
Grinband Jack, Steffener Jason, Razlighi Qolamreza R, Stern Yaakov
机构信息
Department of Radiology, Columbia University, New York.
Interdisciplinary School of Health Sciences, University of Ottawa, Ontario.
出版信息
Hum Brain Mapp. 2017 Jul;38(7):3538-3551. doi: 10.1002/hbm.23608. Epub 2017 Apr 17.
Abstract
Studies of cognitive function that compare the blood oxygenation level dependent (BOLD) signal across age groups often require the assumption that neurovascular coupling does not change with age. Tests of this assumption have produced mixed results regarding the strength of the coupling and its relative time course. Using deconvolution, we found that age does not have a significant effect on the time course of the hemodynamic impulse response function or on the slope of the BOLD versus stimulus duration relationship. These results suggest that in cognitive studies of healthy aging, group differences in BOLD activation are likely due to age-related changes in cognitive-neural interactions and information processing rather than to impairments in neurovascular coupling. Hum Brain Mapp 38:3538-3551, 2017. © 2017 Wiley Periodicals, Inc.
摘要
比较不同年龄组血氧水平依赖（BOLD）信号的认知功能研究通常需要假设神经血管耦合不会随年龄变化。关于这种耦合的强度及其相对时间进程，对该假设的测试产生了不一致的结果。通过去卷积，我们发现年龄对血流动力学脉冲响应函数的时间进程或BOLD与刺激持续时间关系的斜率没有显著影响。这些结果表明，在健康衰老的认知研究中，BOLD激活的组间差异可能是由于认知-神经相互作用和信息处理中与年龄相关的变化，而不是神经血管耦合受损。《人类大脑图谱》38:3538 - 3551, 2017。© 20
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2
The neuropathology and cerebrovascular mechanisms of dementia.痴呆的神经病理学和脑血管机制。
J Cereb Blood Flow Metab. 2016 Jan;36(1):172-86. doi: 10.1038/jcbfm.2015.164.
3
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PLoS One. 2015 Apr 24;10(4):e0125012. doi: 10.1371/journal.pone.0125012. eCollection 2015.
4
Neural and hemodynamic responses to optogenetic and sensory stimulation in the rat somatosensory cortex.大鼠体感皮层对光遗传学刺激和感觉刺激的神经及血流动力学反应。
J Cereb Blood Flow Metab. 2015 Jun;35(6):922-32. doi: 10.1038/jcbfm.2015.10. Epub 2015 Feb 11.
5
Endothelial cells and human cerebral small vessel disease.内皮细胞与人类脑小血管疾病
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