Klawans H L, Falk D K, Nausieda P A, Weiner W J
Neurology. 1978 Oct;28(10):1064-6. doi: 10.1212/wnl.28.10.1064.
Following 6 years of continuous chlorpromazine therapy for schizophrenia, a young woman developed multifocal tics and vocalizations characteristic of Tourette syndrome. The symptoms first appeared when chlorpromazine was withdrawn. They were permanent, although partially ameliorated by chronic haloperidol therapy. Because of her age and past history, these symptoms were attributed to chronic neuroleptic therapy analogous to neuroleptic-induced tardive dyskinesia, rather than to Tourette syndrome per se. These symptoms suggest that chronic receptor-site blockade can result in hypersensitivity of dopamine receptor sites, and that this may play a role in the pathophysiology of Gilles de la Tourette syndrome. This is the first evidence that hypersensitivity of dopamine receptors is involved in the pathophysiology of Tourette syndrome.
一名年轻女性在接受了6年的氯丙嗪持续治疗以治疗精神分裂症后，出现了抽动秽语综合征特有的多灶性抽搐和发声症状。这些症状首次出现在停用氯丙嗪时。症状持续存在，尽管长期使用氟哌啶醇治疗后有所缓解。鉴于她的年龄和既往病史，这些症状被归因于类似于抗精神病药物所致迟发性运动障碍的慢性抗精神病药物治疗，而非抽动秽语综合征本身。这些症状表明，慢性受体位点阻断可导致多巴胺受体位点超敏，这可能在抽动秽语综合征的病理生理学中起作用。这是多巴胺受体超敏参与抽动秽语综合征病理生理学的首个证据。
