Obeso J A, Rothwell J C, Marsden C D
J Neurol Neurosurg Psychiatry. 1981 Aug;44(8):735-8. doi: 10.1136/jnnp.44.8.735.
EEG events prior to simple tics have been examined in six patients with Gilles de la Tourette's syndrome, and compared to EEG changes occurring when the same subjects voluntarily mimicked their own tics. Voluntary jerks were prefaced by a premovement negative potential commencing about 500 ms prior to the muscle EMG discharge and reaching an amplitude of about 7 muV. No such premovement potential was evident in the EEG prior to spontaneous tics in five of the six patients; a very small event was seen in the sixth patient but it was only about one-tenth of the size of the premovement potential seen prefacing voluntary jerks in the same subject. These data indicate that simple tics in Gilles de la Tourette's syndrome are physiologically distinct from normal self-paced willed movements.
对6例患有抽动秽语综合征的患者，研究了简单抽动之前的脑电图（EEG）事件，并与这些受试者自愿模仿自身抽动时发生的脑电图变化进行了比较。自愿性抽搐之前，在肌肉肌电图放电前约500毫秒开始出现运动前负电位，并达到约7微伏的幅度。6例患者中有5例在自发性抽动之前的脑电图中未出现这种运动前电位；第6例患者出现了一个非常小的事件，但它的大小仅约为同一受试者自愿性抽搐之前所见运动前电位大小的十分之一。这些数据表明，抽动秽语综合征中的简单抽动在生理上与正常的自定节奏的随意运动不同。
