Fan Jiangli, Guo Shigang, Wang Suzhen, Kang Yao, Yao Qichao, Wang Jia, Gao Xue, Wang Hongjiang, Du Jianjun, Peng Xiaojun
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116024, P. R. China.
Chem Commun (Camb). 2017 Apr 27;53(35):4857-4860. doi: 10.1039/c7cc01798g.
The first NIR KIAA1363-targeting probe, NB-AX, specifically and instantly featured an "off-on" switch upon gradual addition of KIAA1363 over all kinds of other biomolecules, and its detection limit was initially calculated to be 0.58 μg mL (3δ/k). The probe was also able to be used in ultrafast distinguishing of breast cancer cells from normal cells in fluorescence imaging and applied in tissue imaging and tumor imaging in vivo.
首个靶向近红外KIAA1363的探针NB-AX，在向各种其他生物分子中逐渐添加KIAA1363时，特异性且即时地呈现出“开启-关闭”开关特性，其检测限最初计算为0.58 μg/mL（3δ/k）。该探针还能够用于在荧光成像中快速区分乳腺癌细胞与正常细胞，并应用于体内组织成像和肿瘤成像。
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