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体重指数对剖宫产产妇发生高位脊髓阻滞风险的影响:一项回顾性队列研究。

The impact of body mass index on the risk of high spinal block in parturients undergoing cesarean delivery: a retrospective cohort study.

作者信息

Lamon Agnes M, Einhorn Lisa M, Cooter Mary, Habib Ashraf S

机构信息

Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC, 27710, USA.

出版信息

J Anesth. 2017 Aug;31(4):552-558. doi: 10.1007/s00540-017-2352-0. Epub 2017 Apr 18.

Abstract

PURPOSE

To investigate the hypothesis that the risk of high spinal block is not increased in obese parturients undergoing cesarean delivery compared to non-obese parturients.

METHODS

This is a retrospective study at an academic center. We searched the perioperative database for women who underwent cesarean delivery under spinal or combined spinal epidural anesthesia with hyperbaric bupivacaine ≥10.5 mg. A body mass index (BMI) ≥30 kg/m was defined as obese. We categorized obesity into: obesity class I (BMI = 30-34.9 kg/m), obesity class II (BMI = 35-39.9 kg/m), obesity class III (BMI = 40-49.9 kg/m), and super obese (BMI ≥50 kg/m). The primary outcome was high spinal block defined as need to convert to general anesthesia within 20 min of spinal placement as a result of altered mental status, weakness, or respiratory distress resulting from the high block, or a recorded block height ≥T1.

RESULTS

The analysis included 5015 women. High spinal blocks occurred in 29 patients (0.6%). The risk of high spinal was significantly different according to BMI (p = 0.025). In a multivariate model, BMI (p = 0.008) and cesarean delivery priority (p = 0.009) were associated with high blocks. BMI ≥50 kg/m was associated with greater odds of high block compared to BMI <30 kg/m [odds ratio (95% confidence interval): 6.3 (2.2, 18.5)]. Scheduled cesarean delivery was also associated with greater odds of high block compared with unscheduled delivery.

CONCLUSIONS

At standard spinal doses of hyperbaric bupivacaine used in our practice (≥10.5 mg), there were greater odds of high block in those with BMI ≥50 kg/m.

摘要

目的

探讨与非肥胖产妇相比,肥胖产妇剖宫产时发生高位脊髓阻滞的风险是否增加这一假设。

方法

这是一项在学术中心开展的回顾性研究。我们在围手术期数据库中搜索了接受腰麻或腰麻-硬膜外联合麻醉且使用≥10.5mg重比重布比卡因进行剖宫产的女性。体重指数(BMI)≥30kg/m²被定义为肥胖。我们将肥胖分为:I类肥胖(BMI = 30 - 34.9kg/m²)、II类肥胖(BMI = 35 - 39.9kg/m²)、III类肥胖(BMI = 40 - 49.9kg/m²)和超级肥胖(BMI≥50kg/m²)。主要结局是高位脊髓阻滞,定义为因高位阻滞导致的精神状态改变、无力或呼吸窘迫,或记录的阻滞平面≥T1,而在腰麻置管后20分钟内需要转为全身麻醉。

结果

分析纳入了5015名女性。29例患者(0.6%)发生了高位脊髓阻滞。根据BMI,高位脊髓阻滞的风险有显著差异(p = 0.025)。在多变量模型中,BMI(p = 0.008)和剖宫产优先级(p = 0.009)与高位阻滞相关。与BMI <30kg/m²相比,BMI≥50kg/m²发生高位阻滞的几率更高[比值比(95%置信区间):6.3(2.2,18.5)]。计划性剖宫产与非计划性剖宫产相比,发生高位阻滞的几率也更高。

结论

在我们的实践中使用的标准腰麻剂量重比重布比卡因(≥10.5mg)下,BMI≥50kg/m²的患者发生高位阻滞的几率更高。

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