铜（II）介导的螯合辅助吲哚、吡唑和吡咯的区域选择性 N-萘基化通过脱氢交叉偶联。
Copper(II)-Mediated Chelation-Assisted Regioselective N-Naphthylation of Indoles, Pyrazoles and Pyrrole through Dehydrogenative Cross-Coupling.
机构信息
Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati-781039, India.
出版信息
J Org Chem. 2017 May 5;82(9):4883-4890. doi: 10.1021/acs.joc.7b00615. Epub 2017 Apr 25.
PMID:28421758
Abstract
A copper-mediated picolinamide directed regioselective cross-coupling of naphthylamines with azoles is developed via C-H functionalization and C-N bond formation. The reaction of indoles leads to the formation of chiral C-N cross-coupled products with functional group tolerance. These reaction conditions can also be extended to the cross-coupling of pyrazole and pyrrole scaffolds.
摘要
一种铜介导的吡啶酰胺导向的萘胺与唑类的区域选择性交叉偶联反应是通过 C-H 功能化和 C-N 键形成来开发的。吲哚的反应导致具有官能团耐受性的手性 C-N 交叉偶联产物的形成。这些反应条件也可以扩展到吡唑和吡咯支架的交叉偶联。
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