酸介导的吡咯并[2,1-a]异喹啉分子间[3 + 2]环加成反应：Lamellarin 核心和 Lamellarin G 三甲醚的全合成。
Acid-Mediated Intermolecular [3 + 2] Cycloaddition toward Pyrrolo[2,1-a]isoquinolines: Total Synthesis of the Lamellarin Core and Lamellarin G Trimethyl Ether.
机构信息
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University , Wuhan, Hubei 430079, P. R. China.
出版信息
Org Lett. 2017 May 5;19(9):2262-2265. doi: 10.1021/acs.orglett.7b00769. Epub 2017 Apr 19.
A novel one-pot reaction has been developed for the efficient synthesis of pyrrolo[2,1-a]isoquinolines and 1-dearyllamellarin core from (E)-(2-nitrovinyl)benzenes and azomethine ylides generated in situ. This strategy provides a concise total synthesis of the lamellarin core and lamellarin G trimethyl ether using electrophilic substitution and palladium-catalyzed Suzuki-Miyaura cross-coupling reactions.
一种新型的一锅反应已经被开发出来，用于从（E）-（2-硝基亚乙烯基）苯和原位生成的亚甲胺叶立德高效合成吡咯并[2,1-a]异喹啉和 1-二芳基拉米林核心。该策略使用亲电取代和钯催化的 Suzuki-Miyaura 交叉偶联反应，提供了拉米林核心和拉米林 G 三甲醚的简洁总合成。
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