Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey , Piscataway, New Jersey 08854, United States.
Department of Chemistry, College of Chemistry and Life Sciences, Zhejiang Normal University , Jinhua 321004, People's Republic of China.
Org Lett. 2017 Dec 1;19(23):6424-6427. doi: 10.1021/acs.orglett.7b03309. Epub 2017 Nov 16.
α-Ketoamides undergo redox-annulations with cyclic secondary amines, such as 1,2,3,4-tetrahydroisoquinoline, pyrrolidine, piperidine, and morpholine. Catalytic amounts of benzoic acid significantly accelerate these transformations. This approach provides polycyclic imidazolidinone derivatives in typically good yields.
α-酮酰胺与环状仲胺（如 1,2,3,4-四氢异喹啉、吡咯烷、哌啶和吗啉）发生氧化还原环化反应。催化量的苯甲酸可显著加速这些转化。该方法通常以较好的收率得到多环咪唑烷酮衍生物。
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