Li Jie, Mao Qi-Qi
Department of Urology, Lishui Central Hospital, The Fifth Affiliated Hospital, Wenzhou Medical University, Lishui, 323000, Zhejiang, China.
Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.
Oncotarget. 2017 Jul 4;8(27):44776-44784. doi: 10.18632/oncotarget.16794.
Previous studies regarding the relationship between legume intake and risk of prostate cancer have reported inconsistent results. We conducted a meta-analysis of prospective cohort studies to summarize evidence on this association. A systematic literature search of articles published through June 2016 was performed using PubMed and Web of Science databases. The combined relative risk (RR) with its 95% confidence interval (CI) for the highest versus the lowest intake of legumes was calculated with a random-effects model. Dose-response meta-analysis was also performed for the studies that provided at least three levels of legume consumption. Ten articles (eight cohorts) reporting 281,034 individuals and 10,234 incident cases were identified. The individuals with high consumption of legumes compared with the reference group experienced a significantly reduced risk for developing prostate cancer (RR: 0.85 [95% CI 0.75-0.96], P = 0.010). Moderate heterogeneity of RRs was observed across these studies (P = 0.064 for heterogeneity, I2 = 45.8 %). Dose-response meta-analysis indicated that the risk of prostate cancer reduced by 3.7% (95% CI 1.5%-5.8%) for each 20 grams per day increment of legume intake. In conclusion, the results from this meta-analysis suggest that a high intake of legumes is associated with a low incidence of prostate cancer.
以往关于豆类摄入量与前列腺癌风险之间关系的研究报告结果并不一致。我们进行了一项前瞻性队列研究的荟萃分析，以总结关于这种关联的证据。使用PubMed和Web of Science数据库对截至2016年6月发表的文章进行了系统的文献检索。采用随机效应模型计算豆类摄入量最高组与最低组的合并相对风险（RR）及其95%置信区间（CI）。对于提供至少三个豆类消费水平的研究，还进行了剂量反应荟萃分析。共识别出10篇文章（8个队列），涉及281,034名个体和10,234例新发病例。与参照组相比，豆类高摄入量个体患前列腺癌的风险显著降低（RR：0.85 [95% CI 0.75 - 0.96]，P = 0.010）。在这些研究中观察到RR存在中度异质性（异质性P = 0.064，I2 = 45.8%）。剂量反应荟萃分析表明，豆类摄入量每增加20克/天，前列腺癌风险降低3.7%（95% CI 1.5% - 5.8%）。总之，这项荟萃分析的结果表明，高豆类摄入量与前列腺癌低发病率相关。
