Meng Hongzhou, Hu Wenyi, Chen Zhaodian, Shen Yuehong
Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Asia Pac J Clin Oncol. 2014 Jun;10(2):133-40. doi: 10.1111/ajco.12067. Epub 2013 Apr 1.
Recent reports have examined the effect of fruit and vegetable intake on the risk of prostate cancer, but the results are inconsistent. A meta-analysis of prospective studies was conducted to arrive at quantitative conclusions about the contribution of vegetable and fruit intake to the incidence of prostate cancer.
A comprehensive, systematic search of medical literature published up to June 2012 was performed to identify relevant studies. Separate meta-analyses were conducted for fruit and vegetable consumption. The presence of publication bias was assessed using Egger and Begg tests.
In total, 16 cohort studies met the inclusion criteria and were included in the meta-analysis. The combined adjusted relative risk comparing highest with lowest categories showed that there was no association between vegetable and fruit consumption and prostate cancer incidence. The pooled relative risk was 0.97 (95%CI 0.93, 1.01) for vegetables and 1.02 (95%CI 0.98, 1.07) for fruit. There is no heterogeneity between the studies. No publication bias was detected.
This meta-analysis suggests that total fruit or vegetable consumption may not exert a protective role in the risk of prostate cancer.
近期报告探讨了水果和蔬菜摄入量对前列腺癌风险的影响，但结果并不一致。进行了一项前瞻性研究的荟萃分析，以就蔬菜和水果摄入量对前列腺癌发病率的影响得出定量结论。
对截至2012年6月发表的医学文献进行全面、系统的检索，以确定相关研究。对水果和蔬菜消费分别进行荟萃分析。使用Egger和Begg检验评估发表偏倚的存在。
共有16项队列研究符合纳入标准并被纳入荟萃分析。将最高类别与最低类别进行比较的合并调整相对风险显示，蔬菜和水果消费与前列腺癌发病率之间没有关联。蔬菜的合并相对风险为0.97（95%置信区间0.93，1.01），水果为1.02（95%置信区间0.98，1.07）。研究之间没有异质性。未检测到发表偏倚。
这项荟萃分析表明，水果或蔬菜的总消费量可能对前列腺癌风险没有保护作用。
