Arthur R R, Shah K V, Charache P, Saral R
Department of Immunology and Infectious Diseases, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205.
J Infect Dis. 1988 Sep;158(3):563-9. doi: 10.1093/infdis/158.3.563.
Fifty-five recipients of bone marrow transplants were monitored prospectively for urinary excretion of BK (BKV) and JC (JCV) viruses and for infections with other viruses. For both BKV and JCV, viruria occurred exclusively in patients who were seropositive at transplantation, a finding indicating that shedding of virus was very likely the result of reactivation. BKV reactivation, which occurred in 26 (55%) of 47 BKV-seropositive patients, was far more common than JCV reactivation, which was detected in only two (7%) of 30 JCV-seropositive patients (P less than .0001). In most patients, BK viruria began two to eight weeks after transplantation and resolved spontaneously after a two- to three-week period. Posttransplantation, there was a temporal pattern in the onsets of infection with the different viruses; herpes simplex virus infections occurred first (mean, 7 d), followed by BKV infections (mean, 33 d) and then cytomegalovirus infections (mean, 51 d). BK viruria was associated with hemorrhagic cystitis.
对55例接受骨髓移植的患者进行了前瞻性监测，以检测BK（BKV）和JC（JCV）病毒的尿液排泄情况以及其他病毒感染情况。对于BKV和JCV，病毒尿仅发生在移植时血清学阳性的患者中，这一发现表明病毒脱落很可能是再激活的结果。BKV再激活发生在47例BKV血清学阳性患者中的26例（55%），远比JCV再激活常见，后者仅在30例JCV血清学阳性患者中的2例（7%）中检测到（P<0.0001）。在大多数患者中，BK病毒尿在移植后2至8周开始，并在2至3周后自行消退。移植后，不同病毒感染的发病存在时间模式；单纯疱疹病毒感染最先出现（平均7天），其次是BKV感染（平均33天），然后是巨细胞病毒感染（平均51天）。BK病毒尿与出血性膀胱炎有关。
