Liaw Yu-Ching, Chen Cheng-Hsu, Shu Kuo-Hsiung, Fang Chiung-Yao, Ou Wei-Chih, Chen Pei-Lain, Shen Cheng-Huang, Lin Mien-Chun, Chang Deching, Wang Meilin
Clinical Research Center, Chung Shan Medical University Hospital, Taichung, Taiwan.
Virus Genes. 2012 Dec;45(3):581-4. doi: 10.1007/s11262-012-0815-9. Epub 2012 Sep 5.
Kidney cells are the common host for JC virus (JCV) and BK virus (BKV). Reactivation of JCV and/or BKV in patients after organ transplantation, such as renal transplantation, may cause hemorrhagic cystitis and polyomavirus-associated nephropathy. Furthermore, JCV and BKV may be shed in the urine after reactivation in the kidney. Rearranged as well as archetypal non-coding control regions (NCCRs) of JCV and BKV have been frequently identified in human samples. In this study, three JC/BK recombined NCCR sequences were identified in the urine of a patient who had undergone renal transplantation. They were designated as JC-BK hybrids 1, 2, and 3. The three JC/BK recombinant NCCRs contain up-stream JCV as well as down-stream BKV sequences. Deletions of both JCV and BKV sequences were found in these recombined NCCRs. Recombination of DNA sequences between JCV and BKV may occur during co-infection due to the relatively high homology of the two viral genomes.
肾细胞是JC病毒（JCV）和BK病毒（BKV）的常见宿主。在器官移植（如肾移植）后的患者中，JCV和/或BKV的重新激活可能会导致出血性膀胱炎和多瘤病毒相关性肾病。此外，JCV和BKV在肾内重新激活后可能会随尿液排出。在人类样本中经常发现JCV和BKV重排以及原型非编码控制区（NCCR）。在本研究中，在一名接受肾移植患者的尿液中鉴定出3个JC/BK重组NCCR序列。它们被命名为JC-BK杂交体1、2和3。这3个JC/BK重组NCCR包含上游JCV以及下游BKV序列。在这些重组NCCR中发现了JCV和BKV序列的缺失。由于两种病毒基因组具有较高的同源性，JCV和BKV之间的DNA序列重组可能在共同感染期间发生。
