Hu Chenghao, Dong Xiaoxia, Wu Junbo, Xiao Feifan, Shang Jun, Liu Liang, Yang Yuan, Luo Dongmei, Li Qiuting, Song Qian, Yang Jingcheng, Zhang Chengdong, Shen Li, Luo Zhiguo
Department of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, PR China.
Department of Pharmacology, School of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, PR China.
Oncotarget. 2017 May 9;8(19):30888-30899. doi: 10.18632/oncotarget.15737.
Gastric cancer (GC) is one of the most common malignancies worldwide. The expression of CD147 protein is associated with GC. However, the clinical role of CD147 in GC has not been investigated extensively. Hence, we focused on studying the association between the expression of CD147 and clinicopathological features of GC patients in this study. Firstly, sixteen publications (1752 cases and 391 controls) and one from our own original research (143 cases) were included in the meta-analysis to obtain a more precise estimation of the diagnostic value of CD147. The results showed that expression rate of CD147 in the GC group is higher than that in control group. Moreover, gender, TNM stage, lymph node metastasis, and depth of invasion are all associated with CD147. Further, sections of gastric tissue from 143 cases underwent immunohistochemical staining for evaluation of CD147 protein expression. Our retrospective analysis demonstrated CD147 protein expression was significantly associated with clinical N stage, and tumor stage. Meanwhile, it can also serve as an independent prognosis biomarker. In conclusion, our results support the role of CD147 as a good indicator of diagnosis and prognosis.
胃癌（GC）是全球最常见的恶性肿瘤之一。CD147蛋白的表达与胃癌有关。然而，CD147在胃癌中的临床作用尚未得到广泛研究。因此，在本研究中我们着重探讨CD147表达与胃癌患者临床病理特征之间的关联。首先，纳入16篇文献（1752例病例和391例对照）以及我们自己的一项原创研究（143例病例）进行荟萃分析，以更精确地评估CD147的诊断价值。结果显示，胃癌组中CD147的表达率高于对照组。此外，性别、TNM分期、淋巴结转移和浸润深度均与CD147有关。进一步地，对143例病例的胃组织切片进行免疫组化染色以评估CD147蛋白表达。我们的回顾性分析表明，CD147蛋白表达与临床N分期及肿瘤分期显著相关。同时，它还可作为一个独立的预后生物标志物。总之，我们的结果支持CD147作为诊断和预后良好指标的作用。
