Department of Internal Medicine and Cardiology, Tama-Nagayama Hospital, Nippon Medical School.
Department of Cardiovascular Medicine, Nippon Medical School.
J Atheroscler Thromb. 2017 Oct 1;24(10):1058-1068. doi: 10.5551/jat.39339. Epub 2017 Apr 19.
Tartrate-resistant acid phosphatase (TRACP)-5b and osteoprotegerin (OPG) are specific and sensitive markers of bone resorption in patients with rheumatoid arthritis (RA) and chronic kidney disease (CKD). The TRACP-5b level is associated with the severity of RA and CKD, while the OPG level is associated with the severity of coronary atherosclerosis and calcification, and can predict a poor outcome in patients with coronary artery disease (CAD). However, the impact of TRACP-5b on coronary atherosclerosis in CAD patients remains unclear.
A total of 71 CAD patients (57 men, 14 women; mean age: 69.0±9.7 years) and 28 age- and gender- matched healthy subjects were investigated. The number of diseased vessels (a marker of the severity of coronary atherosclerosis) and the Gensini score (a marker of the extent of coronary atherosclerosis), as well as the OPG and TRACP-5b levels were measured in CAD patients. The TRACP-5b levels were classified into quartiles.
The TRACP-5b levels were significantly higher in CAD patients than in healthy subjects. Patients with higher TRACP-5b levels had higher OPG levels and Gensini scores than those with lower TRACP-5b levels. Higher TRACP-5b levels were associated with an increased number of diseased vessels. A multivariate linear regression analysis showed that the OPG level and the number of diseased vessels or the Gensini score were significantly and independently associated with the TRACP-5b level.
These data indicate that the TRACP-5b level is significantly associated with the OPG level and with the severity and extent of coronary atherosclerosis in CAD patients.
抗酒石酸酸性磷酸酶 5b（TRACP-5b）和骨保护素（OPG）是类风湿关节炎（RA）和慢性肾脏病（CKD）患者骨吸收的特异性和敏感标志物。TRACP-5b 水平与 RA 和 CKD 的严重程度相关，而 OPG 水平与冠状动脉粥样硬化和钙化的严重程度相关，并可预测冠心病（CAD）患者的不良预后。然而，TRACP-5b 对 CAD 患者冠状动脉粥样硬化的影响尚不清楚。
共纳入 71 例 CAD 患者（57 名男性，14 名女性；平均年龄：69.0±9.7 岁）和 28 名年龄和性别匹配的健康对照者。在 CAD 患者中测量了病变血管数量（冠状动脉粥样硬化严重程度的标志物）和 Gensini 评分（冠状动脉粥样硬化程度的标志物），以及 OPG 和 TRACP-5b 水平。TRACP-5b 水平分为四分位数。
CAD 患者的 TRACP-5b 水平明显高于健康对照者。TRACP-5b 水平较高的患者的 OPG 水平和 Gensini 评分高于 TRACP-5b 水平较低的患者。较高的 TRACP-5b 水平与病变血管数量的增加相关。多元线性回归分析显示，OPG 水平和病变血管数量或 Gensini 评分与 TRACP-5b 水平显著且独立相关。
这些数据表明，TRACP-5b 水平与 OPG 水平以及 CAD 患者冠状动脉粥样硬化的严重程度和程度显著相关。
