Nursing department of Operation theater, Southwest Hospital, Third Military Medical University, 29 Gaotanyan Road, Chongqing, 400038, China.
Department of Anesthesiology, Southwest Hospital, Third Military Medical University, 29 Gaotanyan Road, Chongqing, 400038, China.
Sci Rep. 2017 Apr 20;7(1):991. doi: 10.1038/s41598-017-01116-5.
Povidone-iodine (PVI) is principally used as an antimicrobial agent. It has been found that 0.5% PVI can attenuate congestion, edema and pain induced by pressure sores. Thus this study aimed to assess the effects of 0.5% PVI on acute skin wounds. Four full-thickness excisional wounds were generated on the dorsal skin of male Sprague-Dawley rats with a 10-mm sterile punch. Two wounds were left untreated and the other two were dressed with gauze with 0.5% PVI for 1 hour per day for the first 5 days after injury. 10-mm full-thickness excisional wounds were also generated on the dorsal skin of rats treated with 10 mg/kg SB431542 and all wounds were treated with 0.5% PVI for 5 days. PVI treatment enhanced wound healing via promotion of expression of α SMA and TGF β, neovascularization and re-epithelialization. Interleukin 6 was reduced following PVI treatment. Inhibition of TGF β abolished the effect of PVI treatment on wound closure. These data show that topical application of 0.5% PVI could promote acute skin wound healing though increased expression of TGF β leading to enhanced formation of granulation tissue, even in the absence of obvious infection.
聚维酮碘（PVI）主要用作抗菌剂。研究发现 0.5%PVI 可减轻褥疮引起的充血、水肿和疼痛。因此，本研究旨在评估 0.5%PVI 对急性皮肤伤口的影响。使用 10mm 无菌打孔器在雄性 Sprague-Dawley 大鼠背部皮肤上生成 4 个全层切除伤口。两个伤口未处理，另外两个伤口每天用 0.5%PVI 纱布包扎 1 小时，共 5 天。在接受 10mg/kg SB431542 治疗的大鼠背部皮肤上也生成了 10mm 全层切除伤口，所有伤口均用 0.5%PVI 治疗 5 天。PVI 治疗通过促进 α SMA 和 TGFβ 的表达、新生血管形成和再上皮化来促进伤口愈合。PVI 治疗后白细胞介素 6 减少。TGFβ 抑制消除了 PVI 治疗对伤口闭合的影响。这些数据表明，局部应用 0.5%PVI 可通过增加 TGFβ 的表达促进急性皮肤伤口愈合，从而导致肉芽组织形成增强，即使在没有明显感染的情况下也是如此。
