Tiarasanti Faradila, Sufiawati Irna, Amalia Eri, Sari Kartika Indah, Zubaedah Cucu, Takarini Veni
Department of Oral Medicine, Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia.
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Padjadjaran University, Bandung, Indonesia.
J Exp Pharmacol. 2024 Jan 26;16:25-35. doi: 10.2147/JEP.S443355. eCollection 2024.
Phenolic compounds with antioxidant, antimicrobial, and anti-inflammatory properties have been identified in potatoes ( L.; Solanaceae), which may potentially contribute to wound healing. The study aimed to evaluate the effect of potato peel extract gel Granola variety on oral gingival wound healing in Wistar Rats.
This research was a true experimental in vivo study, involving 30 male Wistar rats, aged 12-14 weeks and weighing approximately 150 to 200 grams. Surgical vertical incisions, each 3 mm in length, were made on the mandibular gingiva. The test group consisted of six subgroups, each comprising 5 rats. The negative control group received a base gel, while treatment groups were given 1% povidone-iodine solution, 0.1% triamcinolone acetonide oral paste, and 2%, 4%, and 6% potato peel extract gel. Wound lengths were measured on days 3, 7, and 14 to evaluate the healing process. Statistical analysis used the ANOVA test, a p-value of < 0.05 was considered statistically significant.
All experimental groups showed a reduction in wound length on days 3, 7, and 14. Notably, the application of 4% and 6% potato peel extract gel formulations facilitated to faster wound healing on day 3, surpassing the povidone-iodine and triamcinolone acetonide groups. However, by days 7 and 14, both the povidone-iodine group and the 6% formulation group demonstrated superior outcomes, although the differences in values were not statistically significant (p < 0.05).
Potato peel extract gel formulations at 4% and 6% concentrations were found to expedite the healing of incision wounds, showing no statistically significant difference from the povidone-iodine and triamcinolone acetonide groups. Therefore, potato peel extract gel holds excellent potential for development as an alternative medicine for natural and safe wound healing therapy.
已在马铃薯（茄科茄属）中鉴定出具有抗氧化、抗菌和抗炎特性的酚类化合物，这些化合物可能对伤口愈合有潜在作用。本研究旨在评估格兰诺拉品种马铃薯皮提取物凝胶对Wistar大鼠口腔牙龈伤口愈合的影响。
本研究为一项真实的体内实验研究，涉及30只12 - 14周龄、体重约150至200克的雄性Wistar大鼠。在下颌牙龈上制作长度均为3毫米的手术垂直切口。试验组由六个亚组组成，每组5只大鼠。阴性对照组接受基础凝胶，治疗组分别给予1%聚维酮碘溶液、0.1%曲安奈德口腔糊剂以及2%、4%和6%的马铃薯皮提取物凝胶。在第3天、第7天和第14天测量伤口长度以评估愈合过程。统计分析采用方差分析检验，p值<0.05被认为具有统计学意义。
所有实验组在第3天、第7天和第14天伤口长度均有所缩短。值得注意的是，在第3天，4%和6%马铃薯皮提取物凝胶制剂的应用促进伤口愈合更快，超过了聚维酮碘和曲安奈德组。然而，到第7天和第14天，聚维酮碘组和6%制剂组均显示出更好的结果，尽管数值差异无统计学意义（p<0.05）。
发现4%和6%浓度的马铃薯皮提取物凝胶制剂可加速切口伤口愈合，与聚维酮碘和曲安奈德组相比无统计学显著差异。因此，马铃薯皮提取物凝胶作为天然安全的伤口愈合治疗替代药物具有极好的开发潜力。
