Gubskiĭ Iu I, Kalinskiĭ M I, Rudnitskaia N D, Zadorina O V, Kurskiĭ M D
Ukr Biokhim Zh (1978). 1988 May-Jun;60(3):46-51.
The vitamin E deficiency in the rat diet was studied for its effect on the activity of Ca2+-pump and phosphorylation of sarcoplasmic reticulum membrane fragments of myocardium. It is shown that under such an antioxidant deficiency ATP-dependent accumulation of calcium is 2.5 times as low, from 490 down to 190 nmol/mg of protein for 5 min. The administration of ionol, a synthetic antioxidant, to animals reduces the level of calcium accumulation, it is 1.8 times as high as that with vitamin E deficiency; cAMP-dependent phosphorylation of the sarcoplasmic reticulum preparation membranes of the test animal myocardium produces a 1.6-2.1 times increase in them of the ATP-dependent accumulation of calcium, the kinetics of Ca2+ accumulation is unchanged.
研究了大鼠饮食中维生素E缺乏对心肌肌浆网膜碎片Ca2+泵活性和磷酸化的影响。结果表明，在这种抗氧化剂缺乏的情况下，ATP依赖的钙积累降低了2.5倍，5分钟内从490 nmol/mg蛋白质降至190 nmol/mg蛋白质。给动物施用合成抗氧化剂离子醇可降低钙积累水平，比维生素E缺乏时高1.8倍；试验动物心肌肌浆网制剂膜的cAMP依赖磷酸化使ATP依赖的钙积累增加了1.6 - 2.1倍，Ca2+积累动力学未改变。
