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在白细胞介素-2存在的情况下培养的淋巴细胞失去趋化能力，但获得抗肿瘤活性。

Lymphocytes incubated in the presence of IL-2 lose the capacity for chemotaxis but acquire antitumor activity.

作者信息

Romanova E A, Dukhanina E A, Sharapova T N, Sashchenko L P, Gnuchev N V, Yashin D V

机构信息

Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.

出版信息

Dokl Biol Sci. 2017 Jan;472(1):31-33. doi: 10.1134/S0012496617010094. Epub 2017 Apr 21.

DOI:10.1134/S0012496617010094
PMID:28429264
Abstract

Naïve non-activated lymphocytes are capable of releasing the chemoattractant complex Tag7-Mts1 and can migrate along the gradient of its concentration. After activation of these cells by IL-2, they acquire the abilities to kill tumor cells and to release the cytotoxic Tag7-Hsp70 complex, which is accompanied by a loss of both the Tag7-Mts1-mediated lymphocyte chemotaxis and the ability to release this chemoattractant into the conditioned medium.

摘要

未活化的幼稚淋巴细胞能够释放趋化因子复合物Tag7-Mts1，并能沿其浓度梯度迁移。这些细胞被白细胞介素-2激活后，获得了杀死肿瘤细胞和释放细胞毒性Tag7-Hsp70复合物的能力，同时Tag7-Mts1介导的淋巴细胞趋化性以及将这种趋化因子释放到条件培养基中的能力均丧失。

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Cell Cycle. 2015;14(22):3635-43. doi: 10.1080/15384101.2015.1104440.
2
The heat shock-binding protein (HspBP1) protects cells against the cytotoxic action of the Tag7-Hsp70 complex.热休克结合蛋白 (HspBP1) 可保护细胞免受 Tag7-Hsp70 复合物的细胞毒性作用。
J Biol Chem. 2011 Mar 25;286(12):10258-64. doi: 10.1074/jbc.M110.163436. Epub 2011 Jan 19.
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Cytotoxic T lymphocytes carrying a pattern recognition protein Tag7 can detect evasive, HLA-negative but Hsp70-exposing tumor cells, thereby ensuring FasL/Fas-mediated contact killing.
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