Halpern M S, Falkowitz K, Branco F, England J M
Wistar Institute, Philadelphia, Pennsylvania 19104.
Virology. 1988 Sep;166(1):248-50. doi: 10.1016/0042-6822(88)90167-5.
Sarcomas arising in FP chickens infected with subgroup B avian sarcoma virus at increasing times posthatch were compared for their capacity to mediate recruitment of new sarcoma cells by infectious virus production. This comparison was premised on the observation that primary sarcoma growth is much slower when older chickens are infected with avian sarcoma virus. As measured in a transplantation assay, no age-related diminution in the recruitment capacity of sarcoma tissue from virus-infected transplant donors was observed, despite the marked age-related differences in their patterns of primary sarcoma growth. These observations establish that a diminished recruitment capacity is not required for slow primary sarcoma growth. The capacity to induce the formation of sarcomas at sites distal to the primary sarcoma was correlated with a strong recruitment capacity.
对孵化后不同时间感染B亚群禽肉瘤病毒的FP鸡所产生的肉瘤，比较其通过产生传染性病毒介导新肉瘤细胞募集的能力。这种比较基于以下观察结果：当老龄鸡感染禽肉瘤病毒时，原发性肉瘤的生长要慢得多。在移植试验中测定发现，尽管原发性肉瘤生长模式存在明显的年龄相关差异，但未观察到病毒感染的移植供体肉瘤组织的募集能力有与年龄相关的降低。这些观察结果表明，原发性肉瘤生长缓慢并不需要降低的募集能力。在原发性肉瘤远端部位诱导形成肉瘤的能力与强大的募集能力相关。
