Stathakis A, Lim K P, Boan P, Lavender M, Wrobel J, Musk M, Heath C H
Department of Microbiology and Infectious Diseases, Royal Perth Hospital, Perth, Western Australia, Australia.
WA Advanced Lung Disease and Lung Transplant Unit, Royal Perth Hospital, Perth, Western Australia, Australia.
Transpl Infect Dis. 2015 Jun;17(3):429-34. doi: 10.1111/tid.12377. Epub 2015 May 19.
Penicillium marneffei is a thermally dimorphic fungus that can cause severe opportunistic infections in endemic regions of Southeast Asia, particularly in individuals infected with human immunodeficiency virus-1, but has rarely been reported in solid organ transplant recipients. Herein, we report the first case, to our knowledge, of P. marneffei infection in a lung transplant recipient, occurring in a 41-year-old woman 28 months post lung transplantation, after recent travel to Vietnam. We have reviewed the literature to derive some management principles for this rare infection in this clinical context. The number of P. marneffei infections in transplant recipients may increase, as a result of increasing rates of transplantation and travel to endemic areas.
马尔尼菲青霉菌是一种温度双态性真菌，可在东南亚流行地区引起严重的机会性感染，尤其是在感染人类免疫缺陷病毒1型的个体中，但在实体器官移植受者中鲜有报道。在此，据我们所知，我们报告了首例肺移植受者发生马尔尼菲青霉菌感染的病例，该病例发生在一名41岁女性肺移植术后28个月，她近期去过越南。我们回顾了文献，以得出针对这种临床背景下罕见感染的一些管理原则。由于移植率和前往流行地区旅行的人数增加，移植受者中马尔尼菲青霉菌感染的病例数可能会上升。
