利用干细胞成分在体外重新组装胚胎。
Reassembling embryos in vitro from component stem cells.
作者信息
Kubaczka Caroline, Daley George Q
机构信息
Stem Cell Transplantation Program, Division of Pediatric Hematology and Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Cell Res. 2017 Aug;27(8):961-962. doi: 10.1038/cr.2017.61. Epub 2017 Apr 21.
Abstract
Researchers at the University of Cambridge, UK have succeeded in reconstructing mouse embryos by combining pluripotent embryonic and multipotent trophoblast stem cells in a 3D scaffold; the study from the laboratory of Professor Zernicka-Goetz, recently published in Science, provides a break-through tool to probe early mammalian development outside the uterus. Achieving a similar feat with human cells might necessitate reconsideration of the 14-day rule as a limitation of such research.
摘要
英国剑桥大学的研究人员通过将多能胚胎干细胞和多能滋养层干细胞在三维支架中结合，成功重构了小鼠胚胎；泽尔尼卡-戈茨教授实验室的这项研究最近发表在《科学》杂志上，它提供了一种突破性工具，用于探究子宫外的早期哺乳动物发育。用人细胞实现类似的成果可能需要重新考虑将14天规则作为此类研究的限制。
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