Exercise, Health, and Technology Center, Shanghai Jiao Tong University, Shanghai, China.
Faculty of Sport Sciences, University of Jyväskylä, Jyväskylä, Finland.
Obesity (Silver Spring). 2017 Jun;25(6):1077-1082. doi: 10.1002/oby.21838. Epub 2017 Apr 21.
To study whether normal-weight obesity in childhood is associated with increased cardiometabolic risk in early adulthood.
This study assessed data for 236 girls followed from prepuberty to early adulthood. Growth chart data were obtained from birth to 18 years. Body composition was assessed by dual-energy x-ray absorptiometry and cardiometabolic risk by calculating continuous clustered risk score (at ages 11, 14, and 18). The association of body weight status with cardiometabolic risk from childhood to early adulthood was examined.
Subjects with normal-weight obesity were virtually indistinguishable from their normal-weight lean peers in terms of relative body weight and BMI but had significantly higher fat mass (7.1-7.3 kg) and cardiometabolic risk already in childhood, and this difference persisted into early adulthood (P < 0.001 for all).
Children and adolescents with normal body weight and high body fat percentage may be at increased risk for cardiometabolic morbidity in adulthood. Body fatness may be of utility in clinical practice to effectively identify children and adolescents at risk and to permit recommendation of lifestyle changes that could translate to lower risks of cardiovascular diseases in the future.
研究儿童期正常体重肥胖是否与成年早期心血管代谢风险增加有关。
本研究评估了从青春期前到成年早期随访的 236 名女孩的数据。从出生到 18 岁获得生长图表数据。通过双能 X 射线吸收法评估身体成分，通过计算连续聚类风险评分（在 11、14 和 18 岁时）评估心血管代谢风险。检查了从儿童期到成年早期体重状况与心血管代谢风险的关联。
与正常体重消瘦的同龄人相比，正常体重肥胖的受试者在相对体重和 BMI 方面几乎没有区别，但在儿童时期就已经有明显更高的脂肪量（7.1-7.3 公斤）和心血管代谢风险，而且这种差异一直持续到成年早期（所有 P<0.001）。
体重正常但体脂百分比高的儿童和青少年可能在成年后患心血管代谢疾病的风险增加。体脂率在临床实践中可能很有用，可以有效识别有风险的儿童和青少年，并建议进行生活方式的改变，从而降低未来患心血管疾病的风险。
