钠钾泵及其他：钠钾ATP酶作为细胞凋亡和自噬的调节因子
Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy.
作者信息
Felippe Gonçalves-de-Albuquerque Cassiano, Ribeiro Silva Adriana, Ignácio da Silva Camila, Caire Castro-Faria-Neto Hugo, Burth Patrícia
机构信息
Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro RJ CEP 21040-900, Brazil.
Laboratorio de Imunofarmacologia, Departamento de Bioquímica, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro RJ CEP 20211-010, Brazil.
出版信息
Molecules. 2017 Apr 21;22(4):578. doi: 10.3390/molecules22040578.
Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as a target for cancer treatment. Cardiotonic steroids (CS) trigger intracellular signalling upon binding to Na/K-ATPase. Normal lung and tumour cells frequently express different pump isoforms. Thus, Na/K-ATPase is a powerful target for lung cancer treatment. Drugs targeting Na/K-ATPase may induce apoptosis and autophagy in transformed cells. We argue that Na/K-ATPase has a role as a potential target in chemotherapy in lung cancer treatment. We discuss the effects of Na/K-ATPase ligands and molecular pathways inducing deleterious effects on lung cancer cells, especially those leading to apoptosis and autophagy.
肺癌是全球癌症死亡的主要原因。钠钾ATP酶已作为癌症治疗的靶点进行研究。强心甾类化合物（CS）与钠钾ATP酶结合后触发细胞内信号传导。正常肺细胞和肿瘤细胞通常表达不同的泵亚型。因此，钠钾ATP酶是肺癌治疗的有力靶点。靶向钠钾ATP酶的药物可能会诱导转化细胞发生凋亡和自噬。我们认为钠钾ATP酶在肺癌化疗中具有潜在靶点的作用。我们讨论了钠钾ATP酶配体的作用以及诱导肺癌细胞产生有害影响的分子途径，尤其是那些导致凋亡和自噬的途径。
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