铑催化的芳酰胺中 C-H 键与炔烃的烯基化反应。
Rhodium-Catalyzed Alkenylation of C-H Bonds in Aromatic Amides with Alkynes.
机构信息
Department of Applied Chemistry, Faculty of Engineering, Osaka University , Suita, Osaka 565-0871, Japan.
出版信息
Org Lett. 2017 May 5;19(9):2234-2237. doi: 10.1021/acs.orglett.7b00709. Epub 2017 Apr 21.
PMID:28430449
Abstract
The rhodium-catalyzed alkenylation of C-H bonds of aromatic amides with alkynes is reported. A variety of functional groups, including OMe, OAc, Br, Cl, and even NO, are applicable to this reaction to give the corresponding hydroarylation products. The presence of an 8-aminoquinoline group as the directing group is crucial for the success of the reaction.
摘要
报道了铑催化的芳酰胺 C-H 键与炔烃的烯基化反应。多种官能团，包括 OMe、OAc、Br、Cl，甚至 NO，都适用于该反应，生成相应的氢芳基化产物。8-氨基喹啉作为导向基团的存在对于反应的成功至关重要。
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