铑催化的模板辅助远程C-H烯基化反应。
Rhodium catalyzed template-assisted distal -C-H olefination.
作者信息
Dutta Uttam, Maiti Sudip, Pimparkar Sandeep, Maiti Siddhartha, Gahan Lawrence R, Krenske Elizabeth H, Lupton David W, Maiti Debabrata
机构信息
Department of Chemistry , IIT Bombay , Powai , Mumbai 400076 , India . Email:
IITB-Monash Research Academy , IIT Bombay , Powai , Mumbai 400 076 , India.
出版信息
Chem Sci. 2019 Jun 21;10(31):7426-7432. doi: 10.1039/c9sc01824g. eCollection 2019 Aug 21.
Rhodium catalysis has been extensively used for -C-H functionalization reactions, and successfully extended to -C-H functionalization. Its application to -C-H activation remains an unmet challenge. Herein we disclose the first example of such a reaction, with the Rh-catalyzed -C-H olefination of arenes. The use of a Si-linked cyanobiphenyl unit as a traceless directing group leads to highly -selective arene-olefin couplings.
铑催化已广泛用于碳氢键官能团化反应，并成功扩展到碳氢键官能团化。其在碳氢键活化方面的应用仍然是一个尚未解决的挑战。在此，我们披露了此类反应的首个实例，即铑催化的芳烃碳氢键烯基化反应。使用硅连接的氰基联苯单元作为无痕导向基团可实现高度选择性的芳烃 - 烯烃偶联反应。
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