Su Xin-Jun, Zeng Xian-Tao, Fang Cheng, Liu Tong-Zu, Wang Xing-Huan
Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Oncotarget. 2017 May 16;8(20):33953-33960. doi: 10.18632/oncotarget.15424.
Inconsistency between reported findings on the association of prostate specific antigen (PSA) gene -158G/A polymorphism with benign prostatic hyperplasia (BPH) susceptibility need a meta-analysis to obtain a more accurate conclusion. A systematic search was conducted in electronic databases for the collection of eligible studies on PSA -158G/A polymorphism and BPH susceptibility. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were then calculated. 7 case-control studies with 758 cases and 752 controls were included into the present meta-analysis. The analysis results showed no significant relationship between PSA -158G/A polymorphism and BPH susceptibility in total analysis. Interestingly, after subgroup analyses based on ethnicity and source of control, the polymorphism reduced the susceptibility of BPH in Caucasian group (AA vs. GG: OR=0.47, 95% CI=0.25-0.89; allele A vs. allele G: OR=0.68, 95% CI=0.49-0.93), but it increased the disease susceptibility in Asian (AA vs. GG: OR=1.63, 95% CI=1.02-2.60; allele A vs. allele G: OR=1.37, 95% CI=1.03-1.83) and population-based (AA vs. GG: OR=2.39, 95% CI=1.07-5.38; allele A vs. allele G: OR=1.83, 95% CI=1.26-2.65) groups. PSA-158G/A polymorphism may be an inhibitor to the incidence of BPH in Caucasians, but it is likely to be a susceptible factor in Asians.
关于前列腺特异性抗原（PSA）基因-158G/A多态性与良性前列腺增生（BPH）易感性之间关联的报道结果存在不一致性，需要进行荟萃分析以得出更准确的结论。我们在电子数据库中进行了系统检索，以收集关于PSA -158G/A多态性与BPH易感性的合格研究。然后计算合并比值比（OR）和95%置信区间（95%CI）。本荟萃分析纳入了7项病例对照研究，共758例病例和752例对照。分析结果显示，在总体分析中，PSA -158G/A多态性与BPH易感性之间无显著关系。有趣的是，在基于种族和对照来源进行亚组分析后，该多态性降低了白种人群中BPH的易感性（AA与GG相比：OR = 0.47，95%CI = 0.25 - 0.89；等位基因A与等位基因G相比：OR = 0.68，95%CI = 0.49 - 0.93），但在亚洲人群（AA与GG相比：OR = 1.63，95%CI = 1.02 - 2.60；等位基因A与等位基因G相比：OR = 1.37，95%CI = 1.03 - 1.83）和基于人群的研究（AA与GG相比：OR = 2.39，95%CI = 1.07 - 5.38；等位基因A与等位基因G相比：OR = 1.83，95%CI = 1.26 - 2.65）中增加了疾病易感性。PSA-158G/A多态性可能是白种人BPH发病的抑制剂，但在亚洲人中可能是一个易感因素。
