Paleos Constantinos M, Sideratou Zili, Tsiourvas Dimitris
NCSR "Demokritos", Institute of Nanoscience and Nanotechnology , 15310 Aghia Paraskevi, Attiki Greece.
Regulon AE , Apollonos 1, 19400 Koropi, Attiki Greece.
Bioconjug Chem. 2017 Jun 21;28(6):1611-1624. doi: 10.1021/acs.bioconjchem.7b00186. Epub 2017 May 10.
The advantageous biological properties of hydroxyethyl starch (HES) triggered research interest toward the design and synthesis of drug delivery systems (DDSs) based on this polysaccharide. Convenient reaction schemes, including one-step reactions, led to the synthesis of HES conjugates with selected anticancer molecules or therapeutic proteins. Nanocapsules and hydrogels based on HES were also prepared and studied as prospective drug delivery systems. Formulations originating from these drug conjugates and also from nanocapsules and hydrogels loaded with drugs were characterized, highlighting the extension of their half-life in plasma, which is a critical property as far as their efficacy is concerned. Results obtained in vitro and in vivo proved promising, justifying the undertaking of additional experiments with such systems, including their multifunctionalization. The promising formulations that are discussed in this Topical Review is expected to further increase interest in applying HES for molecular constructing novel DDSs with enhanced efficacy, which may, in the future, find clinical applications.
羟乙基淀粉（HES）具有的有利生物学特性引发了人们对基于这种多糖设计和合成药物递送系统（DDS）的研究兴趣。便捷的反应方案，包括一步反应，促成了与选定抗癌分子或治疗性蛋白质的HES缀合物的合成。基于HES的纳米胶囊和水凝胶也作为潜在的药物递送系统被制备和研究。源自这些药物缀合物以及负载药物的纳米胶囊和水凝胶的制剂得到了表征，突出了它们在血浆中半衰期的延长，就其疗效而言这是一个关键特性。体外和体内获得的结果证明很有前景，这为对此类系统开展包括多功能化在内的更多实验提供了依据。本专题综述中讨论的有前景的制剂有望进一步提高人们对应用HES构建具有更高疗效的新型DDS进行分子研究的兴趣，这些制剂未来可能会找到临床应用。
