Department of Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55128 Mainz, Germany.
Max Planck Institute for Polymer Research (MPIP), Ackermannweg 10, 55128 Mainz, Germany.
Cells. 2020 Sep 12;9(9):2087. doi: 10.3390/cells9092087.
Herein, we report the synthesis of carbohydrate and glycodendron structures for dendritic cell targeting, which were subsequently bound to hydroxyethyl starch (HES) nanocapsules prepared by the inverse miniemulsion technique. The uptake of the carbohydrate-functionalized HES nanocapsules into immature human dendritic cells (hDCs) revealed a strong dependence on the used carbohydrate. A multivalent mannose-terminated dendron was found to be far superior in uptake compared to the structurally more complex oligosaccharides used.
在此，我们报告了用于树突状细胞靶向的碳水化合物和糖基化树突结构的合成，随后将其与通过反相细乳液技术制备的羟乙基淀粉（HES）纳米胶囊结合。碳水化合物功能化的 HES 纳米胶囊进入未成熟的人树突状细胞（hDC）的摄取强烈依赖于所用的碳水化合物。与使用的结构更复杂的寡糖相比，发现多价末端为甘露糖的树突在摄取方面具有优异的性能。
