肌少脂性肥胖：中年和老年女性中的流行情况及与虚弱和身体机能的关系。
Osteosarcopenic Obesity: Prevalence and Relation With Frailty and Physical Performance in Middle-Aged and Older Women.
机构信息
Instituto Nacional de Geriatría, Mexico City, Mexico.
Instituto Nacional de Geriatría, Mexico City, Mexico.
出版信息
J Am Med Dir Assoc. 2017 Aug 1;18(8):733.e1-733.e5. doi: 10.1016/j.jamda.2017.02.023. Epub 2017 Apr 18.
OBJECTIVES
The aims of this study were to determine the prevalence of osteosarcopenic obesity (OSO) and to investigate its association with frailty and physical performance in Mexican community-dwelling middle-aged and older women.
DESIGN
Cross-sectional analysis of a prospective cohort.
SETTING
The FraDySMex study, a 2-round evaluation of community-dwelling adults from 2 municipalities in Mexico City.
PARTICIPANTS
Participants were 434 women aged 50 years or older, living in the designated area in Mexico City.
MEASUREMENTS
Body composition was measured with dual-energy X-ray absorptiometry and OSO was defined by the coexistence of sarcopenia, osteopenia, or osteoporosis and obesity. Information regarding demographic characteristics; comorbidities; mental status; nutritional status; and history of falls, fractures, and hospitalization was obtained from questionnaires. Objective measurements of muscle strength and function were grip strength using a hand dynamometer, 6-meter gait speed using a GAIT Rite instrumented walkway, and lower extremity functioning measured by the Short Physical Performance Battery (SPPB). Frailty was assessed using the Frailty Phenotype (Fried criteria), the Gerontopole Frailty Screening Tool (GFST), and the FRAIL scale, to build 3 logistic regression models.
RESULTS
The prevalence of OSO was 19% (n = 81). Frailty (according to the Frailty Phenotype and the GFST) and poor physical performance measured by the SPPB were independently associated with OSO, controlled by age. In the logistic regression model assessing frailty with the Frailty Phenotype, the odds ratio (95% confidence interval) for frailty was 4.86 (2.47-9.55), and for poor physical performance it was 2.11 (1.15-3.89). In the model assessing frailty with the GFST, it was 2.12 (1.10-4.11), and for poor physical performance it was 2.15 (1.18-3.92). Finally, in the model with the FRAIL scale, it was 1.69 (0.85-3.36) for frailty and 2.29 (1.27-4.15) for poor physical performance.
CONCLUSION
OSO is a frequent condition in middle-aged and older women, and it is independently associated with frailty and poor physical performance.
目的
本研究旨在确定墨西哥社区中老年女性中存在的骨质减少性肌肉减少性肥胖（OSO）的流行情况，并探讨其与虚弱和身体机能的关系。
设计
前瞻性队列的横断面分析。
地点
FraDySMex 研究，这是对墨西哥城两个城市社区居民进行的两轮评估。
参与者
参与者为 434 名年龄在 50 岁或以上、居住在墨西哥城指定区域的女性。
测量方法
采用双能 X 射线吸收法测量身体成分，OSO 的定义为肌肉减少症、骨质疏松症或骨量减少症与肥胖并存。通过问卷调查获取人口统计学特征、合并症、精神状态、营养状况以及跌倒、骨折和住院史等信息。使用手持测力计测量握力、GAIT Rite 仪器化步道测量 6 米步行速度以及短体物理表现电池（SPPB）测量下肢功能，对肌肉力量和功能进行客观测量。使用衰弱表型（Fried 标准）、Gerontopole 衰弱筛查工具（GFST）和 FRAIL 量表评估衰弱，并构建 3 个逻辑回归模型。
结果
OSO 的患病率为 19%（n=81）。衰弱（根据衰弱表型和 GFST）和 SPPB 测量的身体机能不良与 OSO 独立相关，控制因素为年龄。在使用衰弱表型评估衰弱的逻辑回归模型中，衰弱的优势比（95%置信区间）为 4.86（2.47-9.55），身体机能不良的优势比为 2.11（1.15-3.89）。在使用 GFST 评估衰弱的模型中，优势比为 2.12（1.10-4.11），身体机能不良的优势比为 2.15（1.18-3.92）。最后，在使用 FRAIL 量表的模型中，衰弱的优势比为 1.69（0.85-3.36），身体机能不良的优势比为 2.29（1.27-4.15）。
结论
OSO 在中老年女性中较为常见，与虚弱和身体机能不良独立相关。
Zotero 插件