运动对患有肌少性肥胖症的老年人的影响：一项随机对照试验的系统评价和荟萃分析

Effects of exercise in older adults with osteosarcopenic adiposity: a systematic review and meta-analysis of randomized controlled trials.

作者信息

Chen Lei, Zhou Wenlu, Li Ju, Xu Taotao, Shi Zhenyu

机构信息

The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), 54 Youdian Road, Hangzhou, Zhejiang Province, 310053, China.

Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou, Zhejiang Province, 310006, China.

出版信息

BMC Musculoskelet Disord. 2025 Apr 8;26(1):342. doi: 10.1186/s12891-025-08581-4.

DOI:10.1186/s12891-025-08581-4

PMID:40200219

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11980054/

Abstract

AIM

To evaluate the effects of exercise training on patients with osteosarcopenic adiposity (OSA).

METHODS

A comprehensive search was conducted in PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, and VIP databases for randomized controlled trials (RCTs) on exercise treatment for OSA patients. The search included both Chinese and English literature up to April 2024. Reference lists and grey literature were also reviewed. Two researchers independently screened the literature, extracted data, and assessed the quality of included studies. Meta-analysis was performed using RevMan 5.4 software.

RESULTS

A total of 7 studies were included in this meta-analysis. Exercise interventions significantly improved bone mineral density (BMD) (MD = 0.0195, 95% CI: 0 to 0.02, P = 0.03), body fat (BF) (MD = -4.0, 95% CI: -5.46 to -2.54, P < 0.01), and hand grip strength (HGS) (MD = 3.13, 95% CI: 0.72 to 5.54, P = 0.01) in patients with OSA. However, no significant differences were observed in skeletal muscle mass index (SMI) (MD = 0.12, 95% CI: -0.26 to 0.50, P = 0.55), gait speed (GS) (SMD = 0.75, 95% CI: -1.26 to 2.76, P = 0.47), or C-reactive protein (CRP) (MD = -0.23, 95% CI: -0.90 to 0.44, P = 0.50).

CONCLUSION

Exercise interventions can effectively improve clinical symptoms and signs in OSA patients to varying degrees, highlighting the importance of exercise in the management of OSA.

摘要

目的

评估运动训练对肥胖型肌少症性骨质疏松症（OSA）患者的影响。

方法

在PubMed、Embase、Cochrane图书馆、科学网、中国知网、万方和维普数据库中进行全面检索，以查找关于OSA患者运动治疗的随机对照试验（RCT）。检索范围包括截至2024年4月的中英文文献。还对参考文献列表和灰色文献进行了审查。两名研究人员独立筛选文献、提取数据并评估纳入研究的质量。使用RevMan 5.4软件进行荟萃分析。

结果

本荟萃分析共纳入7项研究。运动干预显著改善了OSA患者的骨矿物质密度（BMD）（MD = 0.0195，95%CI：0至0.02，P = 0.03）、体脂（BF）（MD = -4.0，95%CI：-5.46至-2.54，P < 0.01）和握力（HGS）（MD = 3.13，95%CI：0.72至5.54，P = 0.01）。然而，在骨骼肌质量指数（SMI）（MD = 0.12，95%CI：-0.26至0.50，P = 0.55）、步速（GS）（SMD = 0.75，95%CI：-1.26至2.76，P = 0.47）或C反应蛋白（CRP）（MD = -0.23，95%CI：-0.90至0.44，P = 0.50）方面未观察到显著差异。