Taimour Soumia, Zarrouk Moncef, Holst Jan, Rosengren Anders H, Groop Leif, Nilsson Peter M, Gottsäter Anders
a Department of Vascular Diseases , Lund University, Skåne University Hospital , Malmö , Sweden.
b Department of Neuroscience and Physiology , University of Gothenburg , Gothenburg , Sweden.
Scand Cardiovasc J. 2017 Aug;51(4):202-206. doi: 10.1080/14017431.2017.1319971. Epub 2017 Apr 24.
Type 2 diabetes mellitus has been linked to a decreased risk for abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA) development in men. The aim of this study was to evaluate if such an effect is detectable already around the time of diabetes diagnosis.
We cross-sectionally compared aortic diameter at ultrasound screening for AAA in 691 men aged 65 years with incipient or newly diagnosed type 2 diabetes (group A) with 18,262 65-year old control men without diabetes (group B).
Aortic diameter did not differ between groups (18.8[17.4-20.8] vs. 19.0[17.5-28.7] mm; p = 0.43). AAA prevalence was 2.5% in group A and 1.5% in group B (p = .010). In logistic regression taking group differences in body mass index (BMI), smoking, presence of atherosclerotic disease and hypertension into account, the difference in AAA prevalence was no longer significant (p = .15). Among men in group A, C-peptide (r = .093; p = .034), but not HbA1c (r = .060; p = .24) correlated with aortic diameter.
Among 65 year old men aortic diameter and AAA prevalence do not differ between those with newly diagnosed type 2 diabetes and those without diabetes. Putative protective effects of type 2 diabetes mellitus against aortic dilatation and AAA development therefore probably occur later after diagnosis of diabetes.
2型糖尿病与男性腹主动脉瘤（主动脉直径≥30毫米，AAA）发病风险降低有关。本研究的目的是评估在糖尿病诊断时是否就能检测到这种效应。
我们对691名65岁初发或新诊断为2型糖尿病的男性（A组）和18262名65岁无糖尿病的对照男性（B组）进行超声筛查AAA时的主动脉直径进行了横断面比较。
两组间主动脉直径无差异（18.8[17.4 - 20.8] vs. 19.0[17.5 - 28.7]毫米；p = 0.43）。A组AAA患病率为2.5%，B组为1.5%（p = 0.010）。在逻辑回归分析中，考虑到两组在体重指数（BMI）、吸烟、动脉粥样硬化疾病和高血压方面的差异，AAA患病率的差异不再显著（p = 0.15）。在A组男性中，C肽（r = 0.093；p = 0.034）与主动脉直径相关，而糖化血红蛋白（HbA1c）（r = 0.060；p = 0.24）与主动脉直径不相关。
在65岁男性中，新诊断的2型糖尿病患者与无糖尿病患者的主动脉直径和AAA患病率无差异。因此，2型糖尿病对主动脉扩张和AAA发展的假定保护作用可能在糖尿病诊断后较晚出现。
