Eilam David
Department of Zoology, Tel-Aviv University, Ramat Aviv 69978, Israel.
Neurosci Biobehav Rev. 2017 May;76(Pt A):67-76. doi: 10.1016/j.neubiorev.2016.12.034.
The application of similar analyses enables a direct projection from translational research in animals to human studies. Following is an example of how the methodology of a specific animal model of obsessive-compulsive disorder (OCD) was applied to study human patients. Specifically, the quinpirole rat model for OCD was based on analyzing the trajectories of travel among different locales, and scoring the set of acts performed at each locale. Applying this analytic approach in human patients unveiled various aspects of OCD, such as the repetition and addition of acts, incompleteness, and the link between behavior and specific locations. It is also illustrated how the same analytical approach could be applicable to studying other mental disorders. Finally, it is suggested that the development of OCD could be explained by the four-phase sequence of Repetition, Addition, Condensation, and Elimination, as outlined in the study of ontogeny and phylogeny and applied to normal development of behavior. In OCD, this sequence is curtailed, resulting in the abundant repetition and addition of acts.
类似分析方法的应用能够实现从动物转化研究到人体研究的直接推断。以下是一个关于如何将特定强迫症（OCD）动物模型的方法应用于研究人类患者的示例。具体而言，OCD的喹吡罗大鼠模型基于分析在不同场所间的移动轨迹，并对在每个场所执行的一系列行为进行评分。将这种分析方法应用于人类患者揭示了OCD的各个方面，例如行为的重复与增加、不完整性以及行为与特定地点之间的联系。文中还阐述了相同的分析方法如何适用于研究其他精神障碍。最后，研究表明，OCD的发展可以用重复、增加、浓缩和消除这四个阶段的序列来解释，该序列源自个体发生学和系统发育学研究，并应用于行为的正常发展。在OCD中，这个序列被缩短，导致行为大量重复和增加。
