Shirota Yuichiro, Dhaka Suman, Paulus Walter, Sommer Martin
Department of Clinical Neurophysiology, University Medical Center Göttingen, Göttingen, Germany.
Department of Clinical Neurophysiology, University Medical Center Göttingen, Göttingen, Germany; Indian Institute of Technology, Guwahati, Assam, India.
Neurosci Lett. 2017 May 22;650:109-113. doi: 10.1016/j.neulet.2017.04.032. Epub 2017 Apr 21.
Transcranial magnetic stimulation (TMS) with different current directions can activate different sets of neurons. Current direction can also affect the results of repetitive TMS.
To test the influence of uni-directional intermittent theta burst stimulation (iTBS) using different current directions, namely posteroanterior (PA) and anteroposterior (AP), on motor behaviour.
In a cross-over design, PA- and AP-iTBS was applied over the left primary motor cortex in 19 healthy, right-handed volunteers. Performance of a finger-tapping task was recorded before and 0, 10, 20, and 30min after the iTBS. The task was conducted with the right and left hands separately at each time point. As a control, AP-iTBS with reduced intensity was applied to 14 participants in a separate session (AP condition).
The finger-tapping count with the left hand was decreased after PA-iTBS. Neither AP- nor AP-iTBS altered the performance.
Current direction had a significant impact on the after-effects of iTBS.
不同电流方向的经颅磁刺激（TMS）可激活不同组别的神经元。电流方向也会影响重复经颅磁刺激的结果。
测试使用不同电流方向，即后前（PA）和前后（AP）方向的单向间歇性theta爆发刺激（iTBS）对运动行为的影响。
采用交叉设计，对19名健康的右利手志愿者的左侧初级运动皮层施加PA-iTBS和AP-iTBS。在iTBS前以及iTBS后0、10、20和30分钟记录手指敲击任务的表现。在每个时间点分别用右手和左手进行任务。作为对照，在单独的实验环节中对14名参与者施加强度降低的AP-iTBS（AP条件）。
PA-iTBS后左手的手指敲击次数减少。AP-iTBS和降低强度的AP-iTBS均未改变表现。
电流方向对iTBS的后效应有显著影响。
