Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei 230022, China.
eNeuro. 2021 Feb 1;8(1). doi: 10.1523/ENEURO.0392-20.2020. Print 2021 Jan-Feb.
Noninvasive brain stimulation to enhance cognition is an area of increasing research interest. Theta burst stimulation (TBS) is a novel accelerated form of stimulation, which more closely mimics the brain's natural firing patterns and may have greater effects on cognitive performance. We report here the comparative assessment of the effect of conventional high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) protocols and TBS protocols on cognition enhancement in healthy controls. Sixty healthy adults (34 males and 26 females) were randomized and counterbalanced and assigned to HF-rTMS ( = 20), TBS ( = 20), or sham ( = 20) groups. The promotion effects of different parameters of prefrontal stimulation on working memory and executive function were compared, as assessed by performance in N-back tasks and the Wisconsin Card Sorting Test (WCST). Both HF-rTMS and intermittent TBS (iTBS) groups displayed a significant improvement in N-back tasks, with an effect size of 0.79 and 1.50, respectively. Furthermore, the iTBS group displayed a significant improvement in the WCST, with an effect size of 0.84. The iTBS group demonstrated higher effect sizes than the HF-rTMS group (=2.68, =0.011), with an effect size of 0.85. However, no improvement in other tasks was observed (>0.05). Intermittent TBS has a stronger cognitive promoting effect than conventional rTMS. In summary, our findings provide direct evidence that iTBS may be a superior protocol for cognitive promotion.
非侵入性脑刺激以增强认知是一个越来越受到关注的研究领域。θ爆发刺激(TBS)是一种新颖的加速刺激形式,更能模拟大脑的自然放电模式,可能对认知表现产生更大的影响。我们在此报告了比较评估传统高频重复经颅磁刺激(HF-rTMS)方案和 TBS 方案对健康对照组认知增强的效果。60 名健康成年人(34 名男性和 26 名女性)被随机分组和平衡分配到 HF-rTMS(n=20)、TBS(n=20)或假刺激(n=20)组。通过 N 回任务和威斯康星卡片分类测试(WCST)评估前额叶刺激不同参数对工作记忆和执行功能的促进作用。HF-rTMS 和间歇性 TBS(iTBS)组在 N 回任务中均显示出显著的改善,效应量分别为 0.79 和 1.50。此外,iTBS 组在 WCST 中显示出显著的改善,效应量为 0.84。iTBS 组的效应量高于 HF-rTMS 组(=2.68,=0.011),效应量为 0.85。然而,在其他任务中没有观察到改善(>0.05)。间歇性 TBS 对认知的促进作用强于传统 rTMS。总之,我们的发现提供了直接证据,表明 iTBS 可能是一种更好的认知促进方案。