Boersma D, McGill S M, Mollenkamp J W, Roufa D J
Proc Natl Acad Sci U S A. 1979 Jan;76(1):415-9. doi: 10.1073/pnas.76.1.415.
Emr-2 is an emetine-resistant (Emr) Chinese hamster ovary cell mutant that contains a single electrophoretically altered ribosomal protein, a component of its 40S ribosomal subunit [Boersma, D., McGill, S., Mollenkamp, J. & Roufa, D.J. (1979) J. Biol. Chem. 254, in press]. This report describes a genetic experiment designed to test linkage between the genes that specify the altered ribosomal protein, S20*, and emetine resistance in Emr clones that segregated from cultures of Emr-2 cells hybridized with emetine-sensitive cells. The data described indicate that Emr and S20* phenotypes are due to mutations linked to the same chromosome in the Chinese hamster genome; most likely they are due to the same mutation. The data also confirm earlier speculations by others that the Emr locus in Chinese hamster cells is hemizygous.
Emr-2是一种对吐根碱具有抗性（Emr）的中国仓鼠卵巢细胞突变体，其40S核糖体亚基的一个组成部分——核糖体蛋白在电泳上发生了单一改变[博尔斯马，D.，麦吉尔，S.，莫伦坎普，J. & 鲁法，D.J.（1979年）《生物化学杂志》254卷，即将发表]。本报告描述了一项遗传实验，旨在测试在与吐根碱敏感细胞杂交的Emr-2细胞培养物中分离出的Emr克隆中，指定改变的核糖体蛋白S20的基因与吐根碱抗性之间的连锁关系。所描述的数据表明，Emr和S20表型是由于与中国仓鼠基因组中同一条染色体连锁的突变所致；很可能它们是由同一个突变引起的。这些数据也证实了其他人早期的推测，即中国仓鼠细胞中的Emr基因座是半合子。
