Qu Hang, Yu Yang, Qin Shu-Cun, Song Guo-Hua
Key Laboratory of Atherosclerosis in Universities of Shandong and Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China.
College of Basic Medicine, Taishan Medical University, Taian 271000, China.
Sheng Li Xue Bao. 2017 Apr 25;69(2):225-234.
High-density lipoprotein (HDL) is composed of apolipoproteins, lipids and functional proteins. HDL protects against atherosclerosis (AS) by reverse cholesterol transport (RCT). HDL inhibits the lipid oxidation, inflammation and restores endothelial function. During systemic inflammation or metabolic disorders, HDL can be modified abnormally and converted to a dysfunctional type, which results in the loss of anti-inflammatory factors including apolipoprotein A-I (apoA-I), paraoxonase (PON) and platelet activating factor acetylhydrolase (PAF-AH), and gains of pro-inflammatory factors such as serum amyloid A (SAA), triglyceride (TG) and oxidative lipid. Therefore, understanding the changes in compositions and biological functions of dysfunctional HDL might help to comprehend its pathogenic mechanism.
高密度脂蛋白（HDL）由载脂蛋白、脂质和功能蛋白组成。HDL通过逆向胆固醇转运（RCT）预防动脉粥样硬化（AS）。HDL抑制脂质氧化、炎症并恢复内皮功能。在全身炎症或代谢紊乱期间，HDL可发生异常修饰并转化为功能失调型，这导致包括载脂蛋白A-I（apoA-I）、对氧磷酶（PON）和血小板活化因子乙酰水解酶（PAF-AH）在内的抗炎因子丧失，以及血清淀粉样蛋白A（SAA）、甘油三酯（TG）和氧化脂质等促炎因子增加。因此，了解功能失调HDL的组成和生物学功能变化可能有助于理解其致病机制。
