Forney K Jean, Brown Tiffany A, Holland-Carter Lauren A, Kennedy Grace A, Keel Pamela K
Department of Psychology, Florida State University, Tallahassee, Florida.
Department of Psychiatry, University of California San Diego, San Diego, California.
Int J Eat Disord. 2017 Aug;50(8):952-962. doi: 10.1002/eat.22717. Epub 2017 Apr 24.
Atypical anorexia nervosa (AAN) is defined by the symptoms of anorexia nervosa in the presence of "significant weight loss" in individuals who are not underweight. Description of current weight in AAN has been limited, significant weight loss has not been defined, and the distinction between having AAN versus having weight suppression has not been examined.
Secondary analyses were conducted with data from an epidemiological study of women (n = 1,640) and men (n = 794). Three definitions of significant weight loss (5, 10, and 15%) for AAN were tested in comparisons with controls and a DSM-5 eating disorder group (DSM-5 ED) on measures of eating pathology and clinical significance using ANCOVA and logistic regression, controlling for age and body mass index. Secondary analyses compared AAN to a weight suppressed group (WS-only) and a cognitive concerns group (COG-only).
Across weight loss thresholds, ≥25% of adults with AAN were currently overweight/obese. At the 5% and 10% definitions, AAN was associated with elevated eating pathology and distress relative to controls, WS-only, and COG-only in women and men. Women with AAN endorsed less eating pathology and distress than DSM-5 ED at some weight loss definitions, whereas men with AAN did not differ from DSM-5 ED in eating pathology or distress.
Results support that even a 5% weight loss, combined with cognitive concerns, may produce a group with a clinically significant eating disorder. AAN was observed in both healthy weight and overweight/obese adults, highlighting the importance of screening for restrictive eating disorders at all weights.
非典型神经性厌食症(AAN)的定义是,在体重未低于正常范围的个体中出现神经性厌食症症状且伴有“显著体重减轻”。目前对AAN患者当前体重的描述有限,“显著体重减轻”尚未明确界定,且未对AAN与体重抑制之间的区别进行研究。
对一项针对女性(n = 1640)和男性(n = 794)的流行病学研究数据进行二次分析。在与对照组和一个DSM-5进食障碍组(DSM-5 ED)的比较中,测试了AAN的三种显著体重减轻定义(5%、10%和15%),使用协方差分析(ANCOVA)和逻辑回归,控制年龄和体重指数,以评估进食病理学和临床意义。二次分析将AAN与体重抑制组(仅WS)和认知关注组(仅COG)进行了比较。
在不同的体重减轻阈值下,≥25%的AAN成年患者目前超重/肥胖。在5%和10%的定义下,与对照组、仅WS组和仅COG组相比,AAN在女性和男性中均与更高的进食病理学和痛苦程度相关。在某些体重减轻定义下,患有AAN的女性比DSM-5 ED患者的进食病理学和痛苦程度更低,而患有AAN的男性在进食病理学或痛苦程度方面与DSM-5 ED患者没有差异。
结果支持,即使体重减轻5%,再加上认知关注,也可能产生一组具有临床显著意义的进食障碍患者。在健康体重和超重/肥胖的成年人中均观察到了AAN,这凸显了对所有体重人群筛查限制性进食障碍的重要性。