[糖尿病足溃疡动物模型及治疗策略的研究进展]
[Research progress on the animal models and treatment strategies of diabetic foot ulcer].
作者信息
Gao Siqian, Shen Yongmei, Geng Funeng, Li Yanhua, Gao Jianqing
机构信息
Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Sichuan Gooddoctor Pharmaceutical Group Co., Ltd., Chengdu 610000, China.
出版信息
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017 Jan 25;46(1):97-105. doi: 10.3785/j.issn.1008-9292.2017.02.15.
Abstract
The suitable experimental animal model is important in research of pathogenesis and therapeutic strategies of diabetic foot ulcer, and the murine model is the most commonly used one at present. It can be divided into two types: the animal model simulating pathological conditions and the model simulating clinical symptoms. This article reviews the current research progress on the mechanisms of diabetic ulcer pathogenesis, and relevant treatment strategies, including the inhibition of matrix metalloproteinases (MMPs) expression, promotion of angiogenesis and anti-inflammatory therapy.
摘要
合适的实验动物模型在糖尿病足溃疡发病机制和治疗策略的研究中至关重要，而小鼠模型是目前最常用的一种。它可分为两类：模拟病理状况的动物模型和模拟临床症状的模型。本文综述了糖尿病溃疡发病机制及相关治疗策略的当前研究进展，包括抑制基质金属蛋白酶（MMPs）表达、促进血管生成和抗炎治疗。
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本文引用的文献
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Sustained release of stromal cell derived factor-1 from an antioxidant thermoresponsive hydrogel enhances dermal wound healing in diabetes.抗氧化温度响应水凝胶持续释放基质细胞衍生因子 1 增强糖尿病皮肤伤口愈合。
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