Gao Siqian, Shen Yongmei, Geng Funeng, Li Yanhua, Gao Jianqing
Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Sichuan Gooddoctor Pharmaceutical Group Co., Ltd., Chengdu 610000, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017 Jan 25;46(1):97-105. doi: 10.3785/j.issn.1008-9292.2017.02.15.
The suitable experimental animal model is important in research of pathogenesis and therapeutic strategies of diabetic foot ulcer, and the murine model is the most commonly used one at present. It can be divided into two types: the animal model simulating pathological conditions and the model simulating clinical symptoms. This article reviews the current research progress on the mechanisms of diabetic ulcer pathogenesis, and relevant treatment strategies, including the inhibition of matrix metalloproteinases (MMPs) expression, promotion of angiogenesis and anti-inflammatory therapy.
合适的实验动物模型在糖尿病足溃疡发病机制和治疗策略的研究中至关重要，而小鼠模型是目前最常用的一种。它可分为两类：模拟病理状况的动物模型和模拟临床症状的模型。本文综述了糖尿病溃疡发病机制及相关治疗策略的当前研究进展，包括抑制基质金属蛋白酶（MMPs）表达、促进血管生成和抗炎治疗。
