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初始矫正率可预测青少年特发性脊柱侧凸患者支具治疗的结果。

Initial Correction Rate Can be Predictive of the Outcome of Brace Treatment in Patients With Adolescent Idiopathic Scoliosis.

作者信息

Xu Leilei, Qin Xiaodong, Qiu Yong, Zhu Zezhang

机构信息

Department of Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.

出版信息

Clin Spine Surg. 2017 May;30(4):E475-E479. doi: 10.1097/BSD.0000000000000343.

Abstract

STUDY DESIGN

A retrospective study.

OBJECTIVE

To determine the definite cut-off value of initial correction rate (ICR) that could be predictive of bracing outcome in patients with adolescent idiopathic scoliosis.

SUMMARY OF BACKGROUND DATA

Earlier studies showed that braced patients with a better ICR could finally have a higher probability of successful outcome. However, it remains controversial what definitive cut-off value of ICR is required to accurately predict the outcome.

MATERIALS AND METHODS

A cohort of 488 adolescent idiopathic scoliosis patients who have completed the brace treatment with a minimum of 2-year follow-up were included in the current study. Curve progression of ≤5 degrees was used to define the success of brace treatment. The success group and the failure group were compared in terms of initial Risser sign, initial age, sex, curve pattern, initial curve magnitude, and ICR. The receiver operating characteristics curve was used to define the definite cut-off point of initial curve correction rate. A logistic regression model was created to determine the independent predictors of the bracing outcome.

RESULTS

At the beginning of brace treatment, the mean age of the cohort was 13.2±1.5 years, and the mean curve magnitude was 29.5 ± 6.6 degrees. At the final follow-up, 368 patients were successfully treated by bracing. Compared with the success group, the failure group was found to have significantly younger age, lower Risser sign, and lower ICR. According to the receiver operating characteristic curve, the best cut-off value of ICR was 10%. The logistic regression model showed that ICR was significantly associated with the outcome of brace treatment with an odds ratio of 9.61.

CONCLUSIONS

Patients with low ICR, low Risser sign, and young age could have a remarkably high risk of bracing failure. A rate of 10% was the optimal cut-off point for ICR, which can be used to effectively stratify braced patients.

摘要

研究设计

一项回顾性研究。

目的

确定初始矫正率(ICR)的明确临界值,该临界值可预测青少年特发性脊柱侧凸患者的支具治疗效果。

背景数据总结

早期研究表明,ICR较好的支具治疗患者最终获得成功结果的可能性更高。然而,准确预测结果所需的ICR明确临界值仍存在争议。

材料与方法

本研究纳入了488例完成支具治疗且至少随访2年的青少年特发性脊柱侧凸患者。支具治疗成功定义为曲线进展≤5度。比较成功组和失败组在初始Risser征、初始年龄、性别、曲线类型、初始曲线大小和ICR方面的差异。采用受试者工作特征曲线确定初始曲线矫正率的明确临界点。建立逻辑回归模型以确定支具治疗效果的独立预测因素。

结果

在支具治疗开始时,该队列的平均年龄为13.2±1.5岁,平均曲线大小为29.5±6.6度。在最终随访时,368例患者通过支具治疗成功。与成功组相比,失败组年龄显著更小、Risser征更低且ICR更低。根据受试者工作特征曲线,ICR的最佳临界值为10%。逻辑回归模型显示,ICR与支具治疗效果显著相关,比值比为9.61。

结论

ICR低、Risser征低且年龄小的患者支具治疗失败风险可能非常高。10%的比率是ICR的最佳临界点,可用于有效分层支具治疗患者。

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