Ma Qiaoqiao, Ding Wanjing, Chen Zhe, Ma Zhongjun
a Institute of Marine Biology, Ocean College , Zhejiang University , Zhoushan , China.
b Zhejiang Provincial Hospital of Traditional Chinese Medicine , Hangzhou , China.
Nat Prod Res. 2018 Apr;32(7):761-766. doi: 10.1080/14786419.2017.1315578. Epub 2017 Apr 24.
Four new bisamides 1-4, and two new rhamnosides (5, 6), along with four known compounds 7-10, were isolated from a scale culture of the mangrove-derived actinomycete Streptomyces sp. SZ-A15. All structures were determined through analysis of the UV, IR, HRESIMS, 1D and 2D NMR spectra as well as by comparison with literature data. BRD4 inhibition of all isolated compounds was evaluated. As for the ability to inhibit protein BRD4, compound 9 exhibited moderate activity with the value of 78.4 ± 2.2% at 10 μM.
从源自红树林的链霉菌属菌株Streptomyces sp. SZ-A15的规模化培养物中分离出4个新的双酰胺类化合物1-4、2个新的鼠李糖苷（5、6）以及4个已知化合物7-10。所有结构均通过紫外光谱、红外光谱、高分辨电喷雾电离质谱、一维和二维核磁共振谱分析以及与文献数据比较来确定。对所有分离得到的化合物进行了BRD4抑制活性评估。就抑制蛋白质BRD4的能力而言，化合物9在10 μM时表现出中等活性，抑制率为78.4 ± 2.2%。
