从深海放线菌链霉菌 lusitanus SCSIO LR32 中分离得到细胞毒蒽环糖苷类糖苷。

Cytotoxic angucycline class glycosides from the deep sea actinomycete Streptomyces lusitanus SCSIO LR32.

机构信息

Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, People's Republic of China.

出版信息

J Nat Prod. 2012 Feb 24;75(2):202-8. doi: 10.1021/np2008335. Epub 2012 Feb 3.

DOI:10.1021/np2008335

PMID:22304344

Abstract

Five new C-glycoside angucyclines, named grincamycins B-F (1-5), and a known angucycline antibiotic, grincamycin (6), were isolated from Streptomyces lusitanus SCSIO LR32, an actinomycete of deep sea origin. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses, including MS and 1D and 2D NMR experiments. All compounds except grincamycin F (5) exhibited in vitro cytotoxicities against the human cancer cell lines HepG2, SW-1990, HeLa, NCI-H460, and MCF-7 and the mouse melanoma cell line B16, with IC₅₀ values ranging from 1.1 to 31 μM.

摘要

从深海来源的放线菌链霉菌 SCSIO LR32 中分离得到了五个新的 C-糖苷类蒽环类抗生素，分别命名为 grincamycins B-F（1-5）和一个已知的蒽环类抗生素 grincamycin（6）。基于广泛的光谱分析，包括 MS 和 1D 和 2D NMR 实验，确定了这些化合物的结构。除了 grincamycin F（5）之外，所有化合物都对 HepG2、SW-1990、HeLa、NCI-H460 和 MCF-7 人癌细胞系和 B16 小鼠黑色素瘤细胞系表现出体外细胞毒性，IC₅₀ 值范围为 1.1 至 31 μM。