Qu Wenjing, Zuo Wenbao, Li Na, Hou Yanhui, Song Zhihua, Gou Guojing, Yang Jianhong
a Department of Pharmaceutics , School of Pharmacy, Ningxia Medical University , Yinchuan , People's Republic of China.
b Department of Pharmaceutical Science , Nanfang Hospital, Southern Medical University , Guangzhou , People's Republic of China.
J Drug Target. 2017 Sep;25(8):661-672. doi: 10.1080/1061186X.2017.1323334. Epub 2017 May 8.
Luminescent semiconductor nanocrystals, also known as quantum dots (QDs), have rich surface chemistry and unique optical properties that make them useful as probes or carriers for molecular diagnostics and therapeutics. However, their potential toxicity and instability in biological environments have puzzled scientific researchers. Much research effort has been devoted to encapsulation of QDs with liposomal hybrids to make them versatile nanocarriers for simultaneous therapeutics and diagnostics (theranostics) and considerable progress has been made over recent years. We provide an overview of the use of QD-liposome complexes (QLCs) for imaging applications, in particular applications in theranostics. More specifically, the design considerations, intracellular uptake and tissue-specific targeting of QLCs are highlighted. Current findings of QLCs for theranostics are discussed. We also discuss the challenges and highlight future directions for applications of liposome-QD hybrid nanocarriers in the biomedical arena.
发光半导体纳米晶体，也被称为量子点（QDs），具有丰富的表面化学性质和独特的光学特性，这使得它们作为分子诊断和治疗的探针或载体很有用。然而，它们在生物环境中的潜在毒性和不稳定性一直困扰着科研人员。大量的研究工作致力于用脂质体杂化物包裹量子点，使其成为用于同步治疗和诊断（治疗诊断学）的多功能纳米载体，并且近年来已经取得了相当大的进展。我们概述了量子点-脂质体复合物（QLCs）在成像应用中的使用情况，特别是在治疗诊断学中的应用。更具体地说，重点介绍了QLCs的设计考量、细胞内摄取和组织特异性靶向。讨论了QLCs用于治疗诊断学的当前研究结果。我们还讨论了挑战，并强调了脂质体-量子点混合纳米载体在生物医学领域应用的未来方向。
