(W. Cai) Departments of Radiology and Medical Physics, University of Wisconsin - Madison, Room 7137, 1111 Highland Avenue, Madison, WI 53705-2275, USA.
Curr Mol Med. 2013 Dec;13(10):1549-67. doi: 10.2174/1566524013666131111121733.
Fluorescent semiconductor quantum dots (QDs) have attracted tremendous attention over the last decade. The superior optical properties of QDs over conventional organic dyes make them attractive labels for a wide variety of biomedical applications, whereas their potential toxicity and instability in biological environment have puzzled scientific researchers. Much research effort has been devoted to surface modification and functionalization of QDs to make them versatile probes for biomedical applications, and significant progress has been made over the last several years. This review article aims to describe the current state-of-the-art of the synthesis, modification, bioconjugation, and applications of QDs for in vivo targeted imaging. In addition, QD-based multifunctional nanoprobes are also summarized.
在过去的十年中，荧光半导体量子点 (QDs) 引起了极大的关注。QDs 在光学性质上优于传统的有机染料，这使得它们成为各种生物医学应用的有吸引力的标记物，而它们在生物环境中的潜在毒性和不稳定性令科学研究人员感到困惑。人们投入了大量的研究努力来对 QDs 进行表面修饰和功能化，以使它们成为生物医学应用的多功能探针，并且在过去的几年中已经取得了重大进展。本文旨在描述 QDs 的合成、修饰、生物偶联和体内靶向成像应用的最新进展。此外，还总结了基于 QD 的多功能纳米探针。
