Virology Laboratory, University Hospital of Strasbourg, F-67000, Strasbourg, France.
INSERM, IRM UMR-S 1109, F-67000, Strasbourg, France.
J Neurovirol. 2017 Aug;23(4):615-620. doi: 10.1007/s13365-017-0525-0. Epub 2017 Apr 24.
Hepatitis E virus (HEV) infection is an emerging autochthonous disease in industrialized countries. Extra-hepatic manifestations, in particular neurologic manifestations, have been reported in HEV infection. Only a few cases of hepatitis E-associated Parsonage-Turner syndrome have been reported, and HEV genotypes were rarely determined. Here, we report the case of a Parsonage-Turner syndrome associated with an acute autochthonous HEV infection in a 55-year-old immunocompetent patient. HEV genomic RNA was detected in serum and cerebrospinal fluid samples (CSF), and molecular phylogenetic analysis of HEV was performed. The interest of this case lies in its detailed description notably the molecular analysis of HEV RNA isolated from serum and CSF. HEV infection should be considered in diagnostic investigations of neurologic manifestations associated with liver function perturbations.
戊型肝炎病毒（HEV）感染是工业化国家中新兴的本土疾病。已有报道称，HEV 感染可引起肝外表现，特别是神经表现。仅有少数与戊型肝炎相关的帕森斯-特纳综合征的病例报道，且很少确定 HEV 基因型。在此，我们报告了一例 55 岁免疫功能正常的患者发生与急性本土 HEV 感染相关的帕森斯-特纳综合征。在血清和脑脊液（CSF）样本中检测到 HEV 基因组 RNA，并对 HEV 进行了分子系统发育分析。本病例的意义在于其详细描述，尤其是对从血清和 CSF 中分离的 HEV RNA 的分子分析。在与肝功能紊乱相关的神经表现的诊断研究中，应考虑 HEV 感染的可能性。
