Andergassen Ulrich, Kölbl Alexandra C, Mumm Jan-Niclas, Mahner Sven, Jeschke Udo
Department of Obstetrics and Gynaecology, Ludwig-Maximilians University of Munich, 80337 Munich, Germany.
Oncol Rep. 2017 May;37(5):3055-3060. doi: 10.3892/or.2017.5512. Epub 2017 Mar 16.
Triple-negative breast cancer is a highly aggressive type of mammalian carcinoma. It is defined by a rather weak expression of estrogen-, progesterone- and Her2-receptor, and is thus difficult to treat, resulting in low disease-free and overall survival rates of the affected patients. Hence it is important to find new therapeutic options. To this aim we analysed the incidence of some molecules from different signal transduction cascades by immunohistochemistry, which are known to correlate with triple-negative breast cancer, and correlated the expression of these molecules to different tumour traits, such as size, grading, menopausal stage, histology, lymph node affection, remote metastasis formation, and to the incidence of local and lymph node recurrence and metastasis by statistical analysis. Statistically significant correlations were found for a number of tumour characteristics and signalling molecules: HIF1α is correlated to tumour grading, β-catenin to the menopausal state of the patient, and for Notch1 a relation to lymph node affection is seen. In terms of different recurrences, a correlation of β-catenin to metastasis formation and lymph node affection could be shown, as well as coherences between XBP1 and lymph node recurrence, Notch1 and metastasis formation and FOXP3 and the occurrence of local recurrence. The presented results are in accordance with formerly published studies and therefore might comprise opportunities to develop new therapeutical strategies, which could help to handle this aggressive form of breast cancer in a manner, by which side effects would be reduced and therapeutical efficiency is increased.
三阴性乳腺癌是一种侵袭性很强的哺乳动物癌。它的定义是雌激素、孕激素和人表皮生长因子受体2（Her2）表达较弱，因此难以治疗，导致受影响患者的无病生存率和总生存率较低。因此，寻找新的治疗方案很重要。为此，我们通过免疫组织化学分析了来自不同信号转导级联的一些分子的发生率，这些分子已知与三阴性乳腺癌相关，并通过统计分析将这些分子的表达与不同的肿瘤特征相关联，如肿瘤大小、分级、绝经状态、组织学、淋巴结受累情况、远处转移形成情况，以及局部和淋巴结复发及转移的发生率。在许多肿瘤特征和信号分子之间发现了具有统计学意义的相关性：缺氧诱导因子1α（HIF1α）与肿瘤分级相关，β-连环蛋白与患者的绝经状态相关，而Notch1与淋巴结受累情况有关。就不同的复发情况而言，可以显示β-连环蛋白与转移形成和淋巴结受累之间的相关性，以及XBP1与淋巴结复发、Notch1与转移形成、叉头框蛋白P3（FOXP3）与局部复发发生之间的相关性。所呈现的结果与先前发表的研究一致，因此可能为开发新的治疗策略提供机会，这有助于以减少副作用并提高治疗效果的方式来应对这种侵袭性乳腺癌。
