Henry Jeffrey L, Posevins Daniels, Yang Bin, Qiu Youai, Bäckvall Jan-E
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.
Chemistry. 2017 Jun 12;23(33):7896-7899. doi: 10.1002/chem.201701654. Epub 2017 May 17.
An olefin-assisted, palladium-catalyzed oxidative alkynylation of enallenes for regio- and stereoselective synthesis of substituted trienynes has been developed. The reaction shows a broad substrate scope and good tolerance for various functional groups on the allene moiety, including carboxylic acid esters, free hydroxyls, imides, and alkyl groups. Also, a wide range of terminal alkynes with electron-donating and electron-withdrawing aryls, heteroaryls, alkyls, trimethylsilyl, and free hydroxyl groups are tolerated.
已开发出一种用于区域和立体选择性合成取代三烯炔的烯丙基辅助、钯催化的烯丙二烯氧化炔基化反应。该反应底物范围广泛，对烯丙二烯部分的各种官能团具有良好的耐受性，包括羧酸酯、游离羟基、酰亚胺和烷基。此外，还能耐受多种带有供电子和吸电子芳基、杂芳基、烷基、三甲基硅基和游离羟基的末端炔烃。
