Ferrer-Cosme Belkis, Téllez-Martínez Damiana, Batista-Duharte Alexander
Departamento de Inmunología, Hospital Clínico-Quirúrgico "Saturnino Lora", Santiago de Cuba, Cuba.
Rev Med Inst Mex Seguro Soc. 2017 May-Jun;55(3):362-373.
Recently Shoenfeld and Agmon-Levin proposed a new clinical entity called autoimmune/inflammatory syndrome induced by adjuvants (ASIA), which includes four clinical entities called: 1) siliconosis, 2) Gulf War syndrome, 3) macrophage myofasciitis) and 4) post-vaccination phenomenon associated with adjuvants. They all have a common denominator: a prior exposure to immunoadjuvants, and, in addition, they also share several clinical criteria associated to chronic inflammation and autoimmune reactions. This proposal still needs to be validated by the scientific community, but nowadays is a topic of hot discussion in the literature and in various international conferences. In this revision article, we analyze the characteristics of this syndrome, the current mechanisms possibly involved in the pathogenesis, and the more recent reports regarding ASIA associated to vaccine and some foreign substances.
最近，绍恩菲尔德和阿格蒙 - 莱文提出了一种名为佐剂诱导的自身免疫/炎症综合征（ASIA）的新临床实体，其中包括四个临床实体，分别为：1）矽肺，2）海湾战争综合征，3）巨噬细胞性肌筋膜炎，以及4）与佐剂相关的疫苗接种后现象。它们都有一个共同特征：先前接触过免疫佐剂，此外，它们还具有一些与慢性炎症和自身免疫反应相关的临床标准。这一提议仍需科学界验证，但如今已成为文献和各种国际会议上热议的话题。在这篇综述文章中，我们分析了该综合征的特征、发病机制中可能涉及的当前机制，以及关于与疫苗和某些外来物质相关的ASIA的最新报道。
